8AV2
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![BU of 8av2 by Molmil](/molmil-images/mine/8av2) | Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ... | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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5K0R
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![BU of 5k0r by Molmil](/molmil-images/mine/5k0r) | Crystal structure of reduced Shewanella Yellow Enzyme 4 (SYE4) | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, NAD(P)H:flavin oxidoreductase Sye4, Octadecane | Authors: | Elegheert, J, Brige, A, Savvides, S.N. | Deposit date: | 2016-05-17 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands. FEBS Lett., 591, 2017
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5K1U
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![BU of 5k1u by Molmil](/molmil-images/mine/5k1u) | |
3QS7
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![BU of 3qs7 by Molmil](/molmil-images/mine/3qs7) | |
2BE7
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![BU of 2be7 by Molmil](/molmil-images/mine/2be7) | Crystal structure of the unliganded (T-state) aspartate transcarbamoylase of the psychrophilic bacterium Moritella profunda | Descriptor: | Aspartate Carbamoyltransferase Catalytic Chain, Aspartate Carbamoyltransferase Regulatory Chain, SULFATE ION, ... | Authors: | De Vos, D, Savvides, S.N, Van Beeumen, J. | Deposit date: | 2005-10-23 | Release date: | 2006-10-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda. J.Mol.Biol., 365, 2007
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3DJG
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![BU of 3djg by Molmil](/molmil-images/mine/3djg) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-23 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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5K1Q
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2HVX
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![BU of 2hvx by Molmil](/molmil-images/mine/2hvx) | Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design | Descriptor: | Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID | Authors: | Greco, M.N, Hawkins, M.J, Powell, E.T, Almond, H.R, de Garavilla, L, Wang, Y, Minor, L.A, Wells, G.I, Di Cera, E, Cantwell, A.M, Savvides, S.N, Damiano, B.P, Maryanoff, B.E. | Deposit date: | 2006-07-31 | Release date: | 2007-06-12 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J.Med.Chem., 50, 2007
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7OPB
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![BU of 7opb by Molmil](/molmil-images/mine/7opb) | IL7R in complex with an antagonist | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ... | Authors: | Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N. | Deposit date: | 2021-05-31 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.144 Å) | Cite: | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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2B4F
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![BU of 2b4f by Molmil](/molmil-images/mine/2b4f) | Structure Of A Cold-Adapted Family 8 Xylanase in complex with substrate | Descriptor: | beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Savvides, S.N, Feller, G, Van Beeumen, J.J. | Deposit date: | 2005-09-23 | Release date: | 2006-09-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Oligosaccharide binding in family 8 glycosidases: crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product. Biochemistry, 45, 2006
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8AVO
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![BU of 8avo by Molmil](/molmil-images/mine/8avo) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.84 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVF
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![BU of 8avf by Molmil](/molmil-images/mine/8avf) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.45 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVE
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![BU of 8ave by Molmil](/molmil-images/mine/8ave) | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (5.62 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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1XWQ
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![BU of 1xwq by Molmil](/molmil-images/mine/1xwq) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J.J, Feller, G. | Deposit date: | 2004-11-02 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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2A8Z
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![BU of 2a8z by Molmil](/molmil-images/mine/2a8z) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | endo-1,4-beta-xylanase | Authors: | Collins, T, De Vos, D, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J, Feller, G. | Deposit date: | 2005-07-10 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase. J.Mol.Biol., 354, 2005
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1XWT
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![BU of 1xwt by Molmil](/molmil-images/mine/1xwt) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J.J, Feller, G. | Deposit date: | 2004-11-02 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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1XW2
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![BU of 1xw2 by Molmil](/molmil-images/mine/1xw2) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | Endo-1,4-beta-Xylanase | Authors: | Collins, T, De Vos, D, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J, Feller, G. | Deposit date: | 2004-10-29 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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8AVD
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![BU of 8avd by Molmil](/molmil-images/mine/8avd) | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) | Descriptor: | Leptin, Leptin receptor, NICKEL (II) ION | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVC
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![BU of 8avc by Molmil](/molmil-images/mine/8avc) | Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | Descriptor: | Leptin, Leptin receptor, NICKEL (II) ION | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVB
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![BU of 8avb by Molmil](/molmil-images/mine/8avb) | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). | Descriptor: | Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-08-26 | Release date: | 2023-04-05 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8B7Q
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![BU of 8b7q by Molmil](/molmil-images/mine/8b7q) | Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor | Authors: | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | Deposit date: | 2022-09-30 | Release date: | 2023-04-05 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (4.02 Å) | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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6GHU
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![BU of 6ghu by Molmil](/molmil-images/mine/6ghu) | |
7NX2
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![BU of 7nx2 by Molmil](/molmil-images/mine/7nx2) | Unbound antigen-binding fragment (FAb) 324 | Descriptor: | FAb 324 Heavy Chain, FAb 324 Light Chain, SULFATE ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX4
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7NWZ
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![BU of 7nwz by Molmil](/molmil-images/mine/7nwz) | ALK:ALKAL2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK and LTK ligand 2, ALK tyrosine kinase receptor | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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