4C7H
 
 | | Leismania major N-myristoyltransferase in complex with a peptidomimetic (-NH2) molecule | | Descriptor: | COENZYME A, DIMETHYL SULFOXIDE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ... | | Authors: | Olaleye, T.O, Brannigan, J.A, Goncalves, V, Roberts, S.M, Leatherbarrow, R.J, Wilkinson, A.J, Tate, E.W. | | Deposit date: | 2013-09-20 | | Release date: | 2014-09-24 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Peptidomimetic Inhibitors of N-Myristoyltransferase from Human Malaria and Leishmaniasis Parasites.
Org.Biomol.Chem., 12, 2014
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3OKP
 | | Crystal structure of Corynebacterium glutamicum PimB' bound to GDP-Man (orthorhombic crystal form) | | Descriptor: | GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE | | Authors: | Batt, S.M, Jabeen, T, Besra, G.S, Futterer, K. | | Deposit date: | 2010-08-25 | | Release date: | 2010-09-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
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3PME
 | | Crystal structure of the receptor binding domain of botulinum neurotoxin C/D mosaic serotype | | Descriptor: | GLYCEROL, SULFATE ION, Type C neurotoxin | | Authors: | Zhang, Y, Buchko, G.W, Qin, L, Robinson, H, Varnum, S.M, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2010-11-16 | | Release date: | 2010-12-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions.
Biochem.Biophys.Res.Commun., 404, 2011
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4A9V
 | | Pseudomonas fluorescens PhoX | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Yong, S.C, Roversi, P, Lillington, J.E.D, Zeldin, O.B, Garman, E.F, Lea, S.M, Berks, B.C. | | Deposit date: | 2011-11-28 | | Release date: | 2012-12-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | A Complex Iron-Calcium Cofactor Catalyzing Phosphotransfer Chemistry
Science, 345, 2014
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3PUF
 | | Crystal structure of human RNase H2 complex | | Descriptor: | Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C | | Authors: | Figiel, M, Chon, H, Cerritelli, S.M, Cybulska, M, Crouch, R.J, Nowotny, M. | | Deposit date: | 2010-12-04 | | Release date: | 2010-12-22 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.
J.Biol.Chem., 286, 2011
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3PPE
 | | Crystal structure of chicken VE-cadherin EC1-2 | | Descriptor: | CALCIUM ION, Vascular endothelial cadherin | | Authors: | Brasch, J, Harrison, O.J, Ahlsen, G, Carnally, S.M, Henderson, R.M, Honig, B, Shapiro, L.S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
J.Mol.Biol., 408, 2011
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4AU7
 | | The structure of the Suv4-20h2 ternary complex with histone H4 | | Descriptor: | 1,2-ETHANEDIOL, HISTONE H4 PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, ... | | Authors: | Southall, S.M, Cronin, N.B, Wilson, J.R. | | Deposit date: | 2012-05-14 | | Release date: | 2013-05-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
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4B03
 | | 6A Electron cryomicroscopy structure of immature Dengue virus serotype 1 | | Descriptor: | DENGUE VIRUS 1 E PROTEIN, DENGUE VIRUS 1 PRM PROTEIN | | Authors: | Kostyuchenko, V.A, Zhang, Q, Tan, L.C, Ng, T.S, Lok, S.M. | | Deposit date: | 2012-06-28 | | Release date: | 2013-06-05 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Immature and Mature Dengue Serotype 1 Virus Structures Provide Insight Into the Maturation Process.
J.Virol., 87, 2013
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4CMV
 | | Crystal structure of Rv3378c | | Descriptor: | CITRIC ACID, DITERPENE SYNTHASE, MERCURY (II) ION | | Authors: | Layre, E, Lee, H.J, Young, D.C, Martinot, A.J, Buter, J, Minnaard, A.J, Annand, J.W, Fortune, S.M, Snider, B.B, Matsunaga, I, Rubin, E.J, Alber, T, Moody, D.B. | | Deposit date: | 2014-01-18 | | Release date: | 2014-02-19 | | Last modified: | 2014-03-12 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Molecular Profiling of Mycobacterium Tuberculosis Identifies Tuberculosinyl Nucleoside Products of the Virulence-Associated Enzyme Rv3378C.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4CGQ
 | | Full length Tah1 bound to HSP90 peptide SRMEEVD | | Descriptor: | CHLORIDE ION, HEAT SHOCK PROTEIN HSP 90-ALPHA, TPR REPEAT-CONTAINING PROTEIN ASSOCIATED WITH HSP90 | | Authors: | Roe, S.M, Pal, M. | | Deposit date: | 2013-11-26 | | Release date: | 2014-12-17 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Tah1 Helix-Swap Dimerization Prevents Mixed Hsp90 Co-Chaperone Complexes
Acta Crystallogr.,Sect.F, 71, 2015
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4CGP
 | | Leishmania major N-myristoyltransferase in complex with cofactor | | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, TETRADECANOYL-COA | | Authors: | Brannigan, J.A, Roberts, S.M, Bell, A.S, Hutton, J.A, Smith, D.F, Tate, E.W, Leatherbarrow, R.J, Wilkinson, A.J. | | Deposit date: | 2013-11-25 | | Release date: | 2014-07-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors
Iucrj, 1, 2014
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3Q7H
 | | Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, CALCIUM ION, DI(HYDROXYETHYL)ETHER | | Authors: | Anderson, S.M, Wawrzak, Z, Gordon, E, Hasseman, J, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-01-04 | | Release date: | 2011-01-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii
To be Published
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4D0E
 | | Human Notch1 EGF domains 11-13 mutant GlcNAc-fucose disaccharide modified at T466 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 | | Authors: | Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. | | Deposit date: | 2014-04-25 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3QEU
 | | The crystal structure of TCR DMF5 | | Descriptor: | DMF5 alpha chain, DMF5 beta chain, GLYCEROL, ... | | Authors: | Borbulevych, O.Y, Santhanagopolan, S.M, Baker, B.M. | | Deposit date: | 2011-01-20 | | Release date: | 2011-07-06 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms.
J.Immunol., 187, 2011
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4BFG
 | | Structure of the extracellular portion of mouse CD200R | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, AZIDE ION, ... | | Authors: | Hatherley, D, Lea, S.M, Johnson, S, Barclay, A.N. | | Deposit date: | 2013-03-18 | | Release date: | 2013-05-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structures of Cd200/Cd200 Receptor Family and Implications for Topology, Regulation, and Evolution
Structure, 21, 2013
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4BFI
 | | Structure of the complex of the extracellular portions of mouse CD200R and mouse CD200 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1, ... | | Authors: | Hatherley, D, Lea, S.M, Johnson, S, Barclay, A.N. | | Deposit date: | 2013-03-19 | | Release date: | 2013-05-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Structures of Cd200/Cd200 Receptor Family and Implications for Topology, Regulation, and Evolution
Structure, 21, 2013
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4BG8
 | | Apo form of a putative sugar kinase MK0840 from Methanopyrus kandleri (monoclinic space group) | | Descriptor: | ACETATE ION, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Schacherl, M, Waltersperger, S.M, Baumann, U. | | Deposit date: | 2013-03-24 | | Release date: | 2013-11-27 | | Last modified: | 2019-03-06 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structural Characterization of the Ribonuclease H-Like Type Askha Superfamily Kinase Mk0840 from Methanopyrus Kandleri
Acta Crystallogr.,Sect.D, 69, 2013
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4CYN
 | | Leishmania major N-myristoyltransferase in complex with an aminoacylpyrrolidine inhibitor (2b) | | Descriptor: | (3R)-3-amino-4-(4-chlorophenyl)-1-[(3R,4S)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]butan-1-one, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | | Authors: | Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. | | Deposit date: | 2014-04-14 | | Release date: | 2014-10-01 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.
J.Med.Chem., 57, 2014
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4CY4
 | | The Cryo-Electron Microscopy Structure of the CorA channel from Methanocaldococcus jannaschii at 21.6 Angstrom in low magnesium. | | Descriptor: | MAGNESIUM TRANSPORT PROTEIN CORA | | Authors: | Cleverley, R.M, Kean, J, Shintre, C.A, Baldock, C, Derrick, J.P, Ford, R.C, Prince, S.M. | | Deposit date: | 2014-04-10 | | Release date: | 2015-04-22 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (21.6 Å) | | Cite: | The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.
Biochim. Biophys. Acta, 1848, 2015
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4CYO
 | | Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 21). | | Descriptor: | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{5-[(3S,4R)-1-[(3R)-3-amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl}-2-(4-fluorophenyl)acetamide, ... | | Authors: | Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. | | Deposit date: | 2014-04-14 | | Release date: | 2014-10-01 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.
J.Med.Chem., 57, 2014
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3N9K
 | | F229A/E292S Double Mutant of Exo-beta-1,3-glucanase from Candida albicans in Complex with Laminaritriose at 1.7 A | | Descriptor: | CALCIUM ION, Glucan 1,3-beta-glucosidase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, ... | | Authors: | Nakatani, Y, Cutfield, S.M, Cutfield, J.F. | | Deposit date: | 2010-05-30 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Carbohydrate binding sites in Candida albicans exo-beta-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance
Febs J., 277, 2010
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4CUD
 | | Human Notch1 EGF domains 11-13 mutant fucosylated at T466 | | Descriptor: | CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, alpha-L-fucopyranose | | Authors: | Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A. | | Deposit date: | 2014-03-18 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4CYP
 | | Leishmania major N-myristoyltransferase in complex with a pyrrolidine inhibitor. | | Descriptor: | (3R)-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]-3-hydroxybutan-1-one, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | | Authors: | Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. | | Deposit date: | 2014-04-14 | | Release date: | 2014-10-22 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.
J.Med.Chem., 57, 2014
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4BQU
 | | Japanin from Rhipicephalus appendiculatus bound to cholesterol: Orthorhombic crystal form | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Roversi, P, Johnson, S, Preston, S, Austyn, J.M, Nuttall, P, Lea, S.M. | | Deposit date: | 2013-06-02 | | Release date: | 2014-06-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.
Sci Rep, 7, 2017
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3QSZ
 | | Crystal Structure of the STAR-related lipid transfer protein (fragment 25-204) from Xanthomonas axonopodis at the resolution 2.4A, Northeast Structural Genomics Consortium Target XaR342 | | Descriptor: | DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, STAR-related lipid transfer protein, ... | | Authors: | Kuzin, A.P, Su, M, Vorobiev, S.M, Sahdev, S, Xiao, R, Ciccosanti, C, Wang, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-02-22 | | Release date: | 2011-04-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.389 Å) | | Cite: | Northeast Structural Genomics Consortium Target XaR342
To be Published
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