4B03
6A Electron cryomicroscopy structure of immature Dengue virus serotype 1
Summary for 4B03
| Entry DOI | 10.2210/pdb4b03/pdb |
| Related | 4AZX |
| EMDB information | 2141 2142 |
| Descriptor | DENGUE VIRUS 1 E PROTEIN, DENGUE VIRUS 1 PRM PROTEIN (2 entities in total) |
| Functional Keywords | virus, flavivirus, prm protein |
| Biological source | DENGUE VIRUS 1 More |
| Cellular location | Virion membrane ; Multi-pass membrane protein : G3F5K5 G3F5K5 |
| Total number of polymer chains | 6 |
| Total formula weight | 216960.14 |
| Authors | Kostyuchenko, V.A.,Zhang, Q.,Tan, L.C.,Ng, T.S.,Lok, S.M. (deposition date: 2012-06-28, release date: 2013-06-05, Last modification date: 2024-05-08) |
| Primary citation | Kostyuchenko, V.A.,Zhang, Q.,Tan, J.L.,Ng, T.S.,Lok, S.M. Immature and Mature Dengue Serotype 1 Virus Structures Provide Insight Into the Maturation Process. J.Virol., 87:7700-, 2013 Cited by PubMed Abstract: Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. PubMed: 23637416DOI: 10.1128/JVI.00197-13 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (6 Å) |
Structure validation
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