4CYN

Leishmania major N-myristoyltransferase in complex with an aminoacylpyrrolidine inhibitor (2b)

Summary for 4CYN

• Entry DOI: 10.2210/pdb4cyn/pdb
• Related: 4CYO 4CYP 4CYQ
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, (3R)-3-amino-4-(4-chlorophenyl)-1-[(3R,4S)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]butan-1-one, ... (5 entities in total)
• Functional Keywords: transferase, myristoylation, inhibitor, drug design
• Biological source: LEISHMANIA MAJOR
• Total number of polymer chains: 1
• Total formula weight: 48919.66

Authors

Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2014-04-14, release date: 2014-10-01, Last modification date: 2014-11-05)

• Primary citation: Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W.; Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.; J.Med.Chem., 57:8664-, 2014; PubMed: 25238611; DOI: 10.1021/JM5011397

Experimental method

X-RAY DIFFRACTION (1.4 Å)