4CYP

Leishmania major N-myristoyltransferase in complex with a pyrrolidine inhibitor.

Summary for 4CYP

Entry DOI	10.2210/pdb4cyp/pdb
Related	4CYN 4CYO 4CYQ
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, (3R)-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]-3-hydroxybutan-1-one, ... (5 entities in total)
Functional Keywords	transferase, myristoylation, inhibitor, drug design
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	1
Total formula weight	48920.64
Authors	Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2014-04-14, release date: 2014-10-22, Last modification date: 2014-11-05)
Primary citation	Hutton, A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57:8664-, 2014 Cited by PubMed: 25238611 DOI: 10.1021/JM5011397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation