3PUF

Crystal structure of human RNase H2 complex

Summary for 3PUF

DescriptorRibonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C, ... (4 entities in total)
Functional Keywordsrnase h fold, triple barrel fold, hydrolase, rnase h
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Probable) O75792 Q5TBB1 Q8TDP1
Total number of polymer chains18
Total molecular weight465896.12
Authors
Figiel, M.,Chon, H.,Cerritelli, S.M.,Cybulska, M.,Crouch, R.J.,Nowotny, M. (deposition date: 2010-12-04, release date: 2010-12-22, Last modification date: 2012-08-29)
Primary citation
Figiel, M.,Chon, H.,Cerritelli, S.M.,Cybulska, M.,Crouch, R.J.,Nowotny, M.
The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.
J.Biol.Chem., 286:10540-10550, 2011
PubMed: 21177858 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.181974
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2733 0.4% 8.0% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02