3PUF

Crystal structure of human RNase H2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J, M...	Ribonuclease H2 subunit A	polymer	302	33724.2	6	UniProt (O75792) Pfam (PF01351) In PDB	Homo sapiens (human)	RNase H2A, RNase H2 subunit A, Aicardi-Goutieres syndrome 4 protein, AGS4, RNase H(35), Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A
2	B, E, H, K, N...	Ribonuclease H2 subunit B	polymer	224	25780.8	6	UniProt (Q5TBB1) Pfam (PF17745) Pfam (PF09468) In PDB	Homo sapiens (human)	RNase H2B, RNase H2 subunit B, Aicardi-Goutieres syndrome 2 protein, AGS2, Deleted in lymphocytic leukemia 8, Ribonuclease HI subunit B
3	C, F, I, L, O...	Ribonuclease H2 subunit C	polymer	167	18144.4	6	UniProt (Q8TDP1) Pfam (PF08615) In PDB	Homo sapiens (human)	RNase H2C, RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C
4		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A, D, G, J, M, P: 1 - 299 (UniProt: O75792)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

B, E, H, K, N, Q: 14 - 233 (UniProt: Q5TBB1)

PDB	External Database	Details
Gly 10	-	expression tag
Ser 11	-	expression tag
His 12	-	expression tag
Met 13	-	expression tag

C, F, I, L, O, R: 1 - 164 (UniProt: Q8TDP1)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	465896.1
All*	Total formula weight	465896.1

*Water molecules are not included.