Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3PUF

Crystal structure of human RNase H2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006298	biological_process	mismatch repair
A	0006401	biological_process	RNA catabolic process
A	0016070	biological_process	RNA metabolic process
A	0032299	cellular_component	ribonuclease H2 complex
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0046872	molecular_function	metal ion binding
B	0032299	cellular_component	ribonuclease H2 complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006298	biological_process	mismatch repair
C	0006401	biological_process	RNA catabolic process
C	0032299	cellular_component	ribonuclease H2 complex
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004519	molecular_function	endonuclease activity
D	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006298	biological_process	mismatch repair
D	0006401	biological_process	RNA catabolic process
D	0016070	biological_process	RNA metabolic process
D	0032299	cellular_component	ribonuclease H2 complex
D	0043137	biological_process	DNA replication, removal of RNA primer
D	0046872	molecular_function	metal ion binding
E	0032299	cellular_component	ribonuclease H2 complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006298	biological_process	mismatch repair
F	0006401	biological_process	RNA catabolic process
F	0032299	cellular_component	ribonuclease H2 complex
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0004519	molecular_function	endonuclease activity
G	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
G	0004540	molecular_function	RNA nuclease activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006298	biological_process	mismatch repair
G	0006401	biological_process	RNA catabolic process
G	0016070	biological_process	RNA metabolic process
G	0032299	cellular_component	ribonuclease H2 complex
G	0043137	biological_process	DNA replication, removal of RNA primer
G	0046872	molecular_function	metal ion binding
H	0032299	cellular_component	ribonuclease H2 complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0006298	biological_process	mismatch repair
I	0006401	biological_process	RNA catabolic process
I	0032299	cellular_component	ribonuclease H2 complex
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0004519	molecular_function	endonuclease activity
J	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
J	0004540	molecular_function	RNA nuclease activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005829	cellular_component	cytosol
J	0006260	biological_process	DNA replication
J	0006298	biological_process	mismatch repair
J	0006401	biological_process	RNA catabolic process
J	0016070	biological_process	RNA metabolic process
J	0032299	cellular_component	ribonuclease H2 complex
J	0043137	biological_process	DNA replication, removal of RNA primer
J	0046872	molecular_function	metal ion binding
K	0032299	cellular_component	ribonuclease H2 complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006298	biological_process	mismatch repair
L	0006401	biological_process	RNA catabolic process
L	0032299	cellular_component	ribonuclease H2 complex
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0004519	molecular_function	endonuclease activity
M	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
M	0004540	molecular_function	RNA nuclease activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005829	cellular_component	cytosol
M	0006260	biological_process	DNA replication
M	0006298	biological_process	mismatch repair
M	0006401	biological_process	RNA catabolic process
M	0016070	biological_process	RNA metabolic process
M	0032299	cellular_component	ribonuclease H2 complex
M	0043137	biological_process	DNA replication, removal of RNA primer
M	0046872	molecular_function	metal ion binding
N	0032299	cellular_component	ribonuclease H2 complex
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0006298	biological_process	mismatch repair
O	0006401	biological_process	RNA catabolic process
O	0032299	cellular_component	ribonuclease H2 complex
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0004519	molecular_function	endonuclease activity
P	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
P	0004540	molecular_function	RNA nuclease activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005829	cellular_component	cytosol
P	0006260	biological_process	DNA replication
P	0006298	biological_process	mismatch repair
P	0006401	biological_process	RNA catabolic process
P	0016070	biological_process	RNA metabolic process
P	0032299	cellular_component	ribonuclease H2 complex
P	0043137	biological_process	DNA replication, removal of RNA primer
P	0046872	molecular_function	metal ion binding
Q	0032299	cellular_component	ribonuclease H2 complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0006298	biological_process	mismatch repair
R	0006401	biological_process	RNA catabolic process
R	0032299	cellular_component	ribonuclease H2 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
C	MET1
J	ASP34
J	GLU35
J	ASP141
M	ASP34
M	GLU35
M	ASP141
P	ASP34
P	GLU35
P	ASP141
F	MET1
I	MET1
L	MET1
O	MET1
R	MET1
G	ASP34
G	GLU35
G	ASP141

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER3
F	SER3
I	SER3
L	SER3
O	SER3
R	SER3

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	THR204
M	THR216
P	THR204
P	THR216
A	THR216
D	THR204
D	THR216
G	THR204
G	THR216
J	THR204
J	THR216
M	THR204

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9CWY8

Chain	Residue	Details
A	SER257
D	SER257
G	SER257
J	SER257
M	SER257
P	SER257

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER277
D	SER277
G	SER277
J	SER277
M	SER277
P	SER277

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)