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3PUF

Crystal structure of human RNase H2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0004518molecular_functionnuclease activity
A0004519molecular_functionendonuclease activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0004540molecular_functionRNA nuclease activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006298biological_processmismatch repair
A0006401biological_processRNA catabolic process
A0016070biological_processRNA metabolic process
A0016787molecular_functionhydrolase activity
A0032299cellular_componentribonuclease H2 complex
A0043137biological_processDNA replication, removal of RNA primer
A0046872molecular_functionmetal ion binding
A0090304biological_processnucleic acid metabolic process
B0032299cellular_componentribonuclease H2 complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006298biological_processmismatch repair
C0006401biological_processRNA catabolic process
C0032299cellular_componentribonuclease H2 complex
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0004518molecular_functionnuclease activity
D0004519molecular_functionendonuclease activity
D0004523molecular_functionRNA-DNA hybrid ribonuclease activity
D0004540molecular_functionRNA nuclease activity
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0006260biological_processDNA replication
D0006298biological_processmismatch repair
D0006401biological_processRNA catabolic process
D0016070biological_processRNA metabolic process
D0016787molecular_functionhydrolase activity
D0032299cellular_componentribonuclease H2 complex
D0043137biological_processDNA replication, removal of RNA primer
D0046872molecular_functionmetal ion binding
D0090304biological_processnucleic acid metabolic process
E0032299cellular_componentribonuclease H2 complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0006298biological_processmismatch repair
F0006401biological_processRNA catabolic process
F0032299cellular_componentribonuclease H2 complex
G0003676molecular_functionnucleic acid binding
G0003723molecular_functionRNA binding
G0004518molecular_functionnuclease activity
G0004519molecular_functionendonuclease activity
G0004523molecular_functionRNA-DNA hybrid ribonuclease activity
G0004540molecular_functionRNA nuclease activity
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005829cellular_componentcytosol
G0006260biological_processDNA replication
G0006298biological_processmismatch repair
G0006401biological_processRNA catabolic process
G0016070biological_processRNA metabolic process
G0016787molecular_functionhydrolase activity
G0032299cellular_componentribonuclease H2 complex
G0043137biological_processDNA replication, removal of RNA primer
G0046872molecular_functionmetal ion binding
G0090304biological_processnucleic acid metabolic process
H0032299cellular_componentribonuclease H2 complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0006298biological_processmismatch repair
I0006401biological_processRNA catabolic process
I0032299cellular_componentribonuclease H2 complex
J0003676molecular_functionnucleic acid binding
J0003723molecular_functionRNA binding
J0004518molecular_functionnuclease activity
J0004519molecular_functionendonuclease activity
J0004523molecular_functionRNA-DNA hybrid ribonuclease activity
J0004540molecular_functionRNA nuclease activity
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005829cellular_componentcytosol
J0006260biological_processDNA replication
J0006298biological_processmismatch repair
J0006401biological_processRNA catabolic process
J0016070biological_processRNA metabolic process
J0016787molecular_functionhydrolase activity
J0032299cellular_componentribonuclease H2 complex
J0043137biological_processDNA replication, removal of RNA primer
J0046872molecular_functionmetal ion binding
J0090304biological_processnucleic acid metabolic process
K0032299cellular_componentribonuclease H2 complex
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0006298biological_processmismatch repair
L0006401biological_processRNA catabolic process
L0032299cellular_componentribonuclease H2 complex
M0003676molecular_functionnucleic acid binding
M0003723molecular_functionRNA binding
M0004518molecular_functionnuclease activity
M0004519molecular_functionendonuclease activity
M0004523molecular_functionRNA-DNA hybrid ribonuclease activity
M0004540molecular_functionRNA nuclease activity
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005829cellular_componentcytosol
M0006260biological_processDNA replication
M0006298biological_processmismatch repair
M0006401biological_processRNA catabolic process
M0016070biological_processRNA metabolic process
M0016787molecular_functionhydrolase activity
M0032299cellular_componentribonuclease H2 complex
M0043137biological_processDNA replication, removal of RNA primer
M0046872molecular_functionmetal ion binding
M0090304biological_processnucleic acid metabolic process
N0032299cellular_componentribonuclease H2 complex
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0006298biological_processmismatch repair
O0006401biological_processRNA catabolic process
O0032299cellular_componentribonuclease H2 complex
P0003676molecular_functionnucleic acid binding
P0003723molecular_functionRNA binding
P0004518molecular_functionnuclease activity
P0004519molecular_functionendonuclease activity
P0004523molecular_functionRNA-DNA hybrid ribonuclease activity
P0004540molecular_functionRNA nuclease activity
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005829cellular_componentcytosol
P0006260biological_processDNA replication
P0006298biological_processmismatch repair
P0006401biological_processRNA catabolic process
P0016070biological_processRNA metabolic process
P0016787molecular_functionhydrolase activity
P0032299cellular_componentribonuclease H2 complex
P0043137biological_processDNA replication, removal of RNA primer
P0046872molecular_functionmetal ion binding
P0090304biological_processnucleic acid metabolic process
Q0032299cellular_componentribonuclease H2 complex
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0006298biological_processmismatch repair
R0006401biological_processRNA catabolic process
R0032299cellular_componentribonuclease H2 complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
CMET1
JASP34
JGLU35
JASP141
MASP34
MGLU35
MASP141
PASP34
PGLU35
PASP141
FMET1
IMET1
LMET1
OMET1
RMET1
GASP34
GGLU35
GASP141

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER3
FSER3
ISER3
LSER3
OSER3
RSER3

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ATHR204
MTHR216
PTHR204
PTHR216
ATHR216
DTHR204
DTHR216
GTHR204
GTHR216
JTHR204
JTHR216
MTHR204

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
ChainResidueDetails
ASER257
DSER257
GSER257
JSER257
MSER257
PSER257

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER277
DSER277
GSER277
JSER277
MSER277
PSER277

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PDB entries from 2024-03-27

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