3PUF

Crystal structure of human RNase H2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006298	biological_process	mismatch repair
A	0006401	biological_process	RNA catabolic process
A	0016070	biological_process	RNA metabolic process
A	0016787	molecular_function	hydrolase activity
A	0032299	cellular_component	ribonuclease H2 complex
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0046872	molecular_function	metal ion binding
B	0032299	cellular_component	ribonuclease H2 complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006298	biological_process	mismatch repair
C	0006401	biological_process	RNA catabolic process
C	0032299	cellular_component	ribonuclease H2 complex
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006298	biological_process	mismatch repair
D	0006401	biological_process	RNA catabolic process
D	0016070	biological_process	RNA metabolic process
D	0016787	molecular_function	hydrolase activity
D	0032299	cellular_component	ribonuclease H2 complex
D	0043137	biological_process	DNA replication, removal of RNA primer
D	0046872	molecular_function	metal ion binding
E	0032299	cellular_component	ribonuclease H2 complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006298	biological_process	mismatch repair
F	0006401	biological_process	RNA catabolic process
F	0032299	cellular_component	ribonuclease H2 complex
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0004518	molecular_function	nuclease activity
G	0004519	molecular_function	endonuclease activity
G	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
G	0004540	molecular_function	RNA nuclease activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006298	biological_process	mismatch repair
G	0006401	biological_process	RNA catabolic process
G	0016070	biological_process	RNA metabolic process
G	0016787	molecular_function	hydrolase activity
G	0032299	cellular_component	ribonuclease H2 complex
G	0043137	biological_process	DNA replication, removal of RNA primer
G	0046872	molecular_function	metal ion binding
H	0032299	cellular_component	ribonuclease H2 complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0006298	biological_process	mismatch repair
I	0006401	biological_process	RNA catabolic process
I	0032299	cellular_component	ribonuclease H2 complex
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0004518	molecular_function	nuclease activity
J	0004519	molecular_function	endonuclease activity
J	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
J	0004540	molecular_function	RNA nuclease activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005829	cellular_component	cytosol
J	0006260	biological_process	DNA replication
J	0006298	biological_process	mismatch repair
J	0006401	biological_process	RNA catabolic process
J	0016070	biological_process	RNA metabolic process
J	0016787	molecular_function	hydrolase activity
J	0032299	cellular_component	ribonuclease H2 complex
J	0043137	biological_process	DNA replication, removal of RNA primer
J	0046872	molecular_function	metal ion binding
K	0032299	cellular_component	ribonuclease H2 complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006298	biological_process	mismatch repair
L	0006401	biological_process	RNA catabolic process
L	0032299	cellular_component	ribonuclease H2 complex
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0004518	molecular_function	nuclease activity
M	0004519	molecular_function	endonuclease activity
M	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
M	0004540	molecular_function	RNA nuclease activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005829	cellular_component	cytosol
M	0006260	biological_process	DNA replication
M	0006298	biological_process	mismatch repair
M	0006401	biological_process	RNA catabolic process
M	0016070	biological_process	RNA metabolic process
M	0016787	molecular_function	hydrolase activity
M	0032299	cellular_component	ribonuclease H2 complex
M	0043137	biological_process	DNA replication, removal of RNA primer
M	0046872	molecular_function	metal ion binding
N	0032299	cellular_component	ribonuclease H2 complex
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0006298	biological_process	mismatch repair
O	0006401	biological_process	RNA catabolic process
O	0032299	cellular_component	ribonuclease H2 complex
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0004518	molecular_function	nuclease activity
P	0004519	molecular_function	endonuclease activity
P	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
P	0004540	molecular_function	RNA nuclease activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005829	cellular_component	cytosol
P	0006260	biological_process	DNA replication
P	0006298	biological_process	mismatch repair
P	0006401	biological_process	RNA catabolic process
P	0016070	biological_process	RNA metabolic process
P	0016787	molecular_function	hydrolase activity
P	0032299	cellular_component	ribonuclease H2 complex
P	0043137	biological_process	DNA replication, removal of RNA primer
P	0046872	molecular_function	metal ion binding
Q	0032299	cellular_component	ribonuclease H2 complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0006298	biological_process	mismatch repair
R	0006401	biological_process	RNA catabolic process
R	0032299	cellular_component	ribonuclease H2 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CWY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	666
Details	Domain: {"description":"RNase H type-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01319","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---