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4CYO

Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 21).

Summary for 4CYO
Entry DOI10.2210/pdb4cyo/pdb
Related4CYN 4CYP 4CYQ
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{5-[(3S,4R)-1-[(3R)-3-amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl}-2-(4-fluorophenyl)acetamide, ... (5 entities in total)
Functional Keywordstransferase, myristoylation, inhibitor, drug design
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight49070.79
Authors
Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2014-04-14, release date: 2014-10-01, Last modification date: 2014-11-05)
Primary citationHutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W.
Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.
J.Med.Chem., 57:8664-, 2014
Cited by
PubMed: 25238611
DOI: 10.1021/JM5011397
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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