1E3O
| Crystal structure of Oct-1 POU dimer bound to MORE | Descriptor: | 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M. | Deposit date: | 2000-06-20 | Release date: | 2001-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
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1HF0
| Crystal structure of the DNA-binding domain of Oct-1 bound to DNA as a dimer | Descriptor: | DNA 5'-D(*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP* CP*AP*AP*AP*TP*GP*GP*AP*G)-3', DNA 5'-D(*CP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP* TP*CP*AP*AP*AP*TP*GP*TP*G)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Scholer, H.R, Wilmanns, M. | Deposit date: | 2000-11-27 | Release date: | 2001-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
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1GT0
| Crystal structure of a POU/HMG/DNA ternary complex | Descriptor: | 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ... | Authors: | Remenyi, A, Wilmanns, M. | Deposit date: | 2002-01-09 | Release date: | 2003-01-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers Genes Dev., 17, 2003
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2F49
| Crystal structure of Fus3 in complex with a Ste5 peptide | Descriptor: | MAGNESIUM ION, Mitogen-activated protein kinase FUS3, STE5 peptide, ... | Authors: | Remenyi, A. | Deposit date: | 2005-11-22 | Release date: | 2006-03-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway Science, 311, 2006
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2B9I
| Crystal structure of Fus3 with a docking motif from Msg5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ... | Authors: | Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A. | Deposit date: | 2005-10-11 | Release date: | 2006-01-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005
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2B9H
| Crystal structure of Fus3 with a docking motif from Ste7 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ... | Authors: | Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A. | Deposit date: | 2005-10-11 | Release date: | 2006-01-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005
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2B9F
| Crystal structure of non-phosphorylated Fus3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3 | Authors: | Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A. | Deposit date: | 2005-10-11 | Release date: | 2006-01-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005
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2B9J
| Crystal structure of Fus3 with a docking motif from Far1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cyclin-dependent kinase inhibitor FAR1, MAGNESIUM ION, ... | Authors: | Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A. | Deposit date: | 2005-10-11 | Release date: | 2006-01-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005
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6ZQS
| Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) | Descriptor: | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 14 | Authors: | Kirsch, K, Sok, P, Poti, A.L, Remenyi, A. | Deposit date: | 2020-07-10 | Release date: | 2020-11-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11, 2020
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6ZR5
| Crystal structure of JNK1 in complex with ATF2(19-58) | Descriptor: | Cyclic AMP-dependent transcription factor ATF-2, MAGNESIUM ION, Mitogen-activated protein kinase 8, ... | Authors: | Kirsch, K, Zeke, A, Remenyi, A. | Deposit date: | 2020-07-10 | Release date: | 2020-11-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.699 Å) | Cite: | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11, 2020
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4NIF
| Heterodimeric structure of ERK2 and RSK1 | Descriptor: | Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1, ... | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2013-11-06 | Release date: | 2014-11-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex Proc.Natl.Acad.Sci.USA, 112, 2015
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3TEI
| Crystal structure of human ERK2 complexed with a MAPK docking peptide | Descriptor: | Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2011-08-15 | Release date: | 2012-08-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.404 Å) | Cite: | Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012
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4LQS
| Crystal structure of the Cbk1-Mob2 kinase-coactivator complex | Descriptor: | CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2013-07-19 | Release date: | 2014-07-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
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4LQP
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4LQQ
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6TCA
| Phosphorylated p38 and MAPKAPK2 complex with inhibitor | Descriptor: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Authors: | Sok, P, Remenyi, A. | Deposit date: | 2019-11-05 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases. Structure, 28, 2020
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4QSY
| SHP2 SH2 domain in complex with GAB1 peptide | Descriptor: | GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2014-07-06 | Release date: | 2015-07-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
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3QBV
| Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin | Descriptor: | Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1 | Authors: | Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T. | Deposit date: | 2011-01-14 | Release date: | 2012-02-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc.Natl.Acad.Sci.USA, 109, 2012
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3FZE
| Structure of the 'minimal scaffold' (ms) domain of Ste5 that cocatalyzes Fus3 phosphorylation by Ste7 | Descriptor: | Protein STE5 | Authors: | Good, M.C, Tang, G, Singleton, J, Remenyi, A, Lim, W.A. | Deposit date: | 2009-01-25 | Release date: | 2009-03-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell(Cambridge,Mass.), 136, 2009
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4IC8
| Crystal structure of the apo ERK5 kinase domain | Descriptor: | Mitogen-activated protein kinase 7 | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2012-12-10 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J.Biol.Chem., 288, 2013
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4IC7
| Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase 7, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Gogl, G, Remenyi, A. | Deposit date: | 2012-12-10 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J.Biol.Chem., 288, 2013
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4FMQ
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2Y9Q
| Crystal structure of human ERK2 complexed with a MAPK docking peptide | Descriptor: | MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1, MITOGEN-ACTIVATED PROTEIN KINASE 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Barkai, T, Garai, A, Toeroe, I, Remenyi, A. | Deposit date: | 2011-02-16 | Release date: | 2012-02-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove. Sci. Signal, 5, 2012
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2XRW
| Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4 | Descriptor: | GLYCEROL, MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS, ... | Authors: | Barkai, T, Toeoroe, I, Garai, A, Remenyi, A. | Deposit date: | 2010-09-23 | Release date: | 2011-09-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove. Sci. Signal, 5, 2012
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2XS0
| Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4 | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3, ... | Authors: | Barkai, T, Toeoroe, I, Garai, A, Remenyi, A. | Deposit date: | 2010-09-24 | Release date: | 2011-09-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove. Sci. Signal, 5, 2012
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