4IC7
Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment
Summary for 4IC7
| Entry DOI | 10.2210/pdb4ic7/pdb |
| Related | 4IC8 |
| Descriptor | Mitogen-activated protein kinase 7, Dual specificity mitogen-activated protein kinase kinase 5, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total) |
| Functional Keywords | kinase domain, signaling protein complex, transferase |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: Q13164 |
| Total number of polymer chains | 4 |
| Total formula weight | 128994.07 |
| Authors | Gogl, G.,Remenyi, A. (deposition date: 2012-12-10, release date: 2013-02-13, Last modification date: 2024-02-28) |
| Primary citation | Glatz, G.,Gogl, G.,Alexa, A.,Remenyi, A. Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J.Biol.Chem., 288:8596-8609, 2013 Cited by PubMed: 23382384DOI: 10.1074/jbc.M113.452235 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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