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4IC7

Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004707molecular_functionMAP kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004707molecular_functionMAP kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ANP A 501
ChainResidue
AGLY62
AMET140
ALEU189
AASP200
AHOH629
AALA65
ATYR66
AVAL69
AALA82
ALYS84
AARG98
AILE115
AASP138

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ANP D 501
ChainResidue
DGLY62
DGLY64
DALA65
DTYR66
DGLY67
DVAL69
DALA82
DLYS84
DARG98
DLEU137
DASP138
DMET140
DLEU189
DASP200

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGAYGVVSsArrrltgqqv.........AIKK
ChainResidueDetails
AILE61-LYS85

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKpsNLLV
ChainResidueDetails
AVAL178-VAL190

site_idPS01351
Number of Residues105
DetailsMAPK MAP kinase signature. FdvvtnakrtlRElkilkhfkhdniiaikdilrptvpygefksvyvvldlmesdlhqiihssqpltlehvryflyqllrglkymhsaqvih........RDlKpsnllvnenC
ChainResidueDetails
APHE90-CYS194

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP182
DASP182

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE61
ALYS84
DILE61
DLYS84

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.7
ChainResidueDetails
AALA2
DALA2

222415

PDB entries from 2024-07-10

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