Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004707 | molecular_function | MAP kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ANP A 501 |
| Chain | Residue |
| A | GLY62 |
| A | MET140 |
| A | LEU189 |
| A | ASP200 |
| A | HOH629 |
| A | ALA65 |
| A | TYR66 |
| A | VAL69 |
| A | ALA82 |
| A | LYS84 |
| A | ARG98 |
| A | ILE115 |
| A | ASP138 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ANP D 501 |
| Chain | Residue |
| D | GLY62 |
| D | GLY64 |
| D | ALA65 |
| D | TYR66 |
| D | GLY67 |
| D | VAL69 |
| D | ALA82 |
| D | LYS84 |
| D | ARG98 |
| D | LEU137 |
| D | ASP138 |
| D | MET140 |
| D | LEU189 |
| D | ASP200 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGAYGVVSsArrrltgqqv.........AIKK |
| Chain | Residue | Details |
| A | ILE61-LYS85 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKpsNLLV |
| Chain | Residue | Details |
| A | VAL178-VAL190 | |
| site_id | PS01351 |
| Number of Residues | 105 |
| Details | MAPK MAP kinase signature. FdvvtnakrtlRElkilkhfkhdniiaikdilrptvpygefksvyvvldlmesdlhqiihssqpltlehvryflyqllrglkymhsaqvih........RDlKpsnllvnenC |
| Chain | Residue | Details |
| A | PHE90-CYS194 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 584 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 122 |
| Details | Region: {"description":"Required for binding to MAP2K5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"TXY"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 182 |
| Details | Domain: {"description":"PB1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01081","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 14 |
| Details | Region: {"description":"Interaction with MAPK7","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with MAP3K2/MAP3K3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
