4IC7

Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Mitogen-activated protein kinase 7	polymer	442	49802.9	2	UniProt (Q13164) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5
2	E, B	Dual specificity mitogen-activated protein kinase kinase 5	polymer	126	14187.9	2	UniProt (Q13163) Pfam (PF00564) In PDB	Homo sapiens (human)	MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5
3	A, D	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4		water	water		18.0	83	Chemie (HOH)

Sequence modifications

A, D: 1 - 431 (UniProt: Q13164)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 432	-	expression tag
Gly 433	-	expression tag
Arg 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag

E, B: 16 - 130 (UniProt: Q13163)

PDB	External Database	Details
Gly 14	-	expression tag
Ser 15	-	expression tag
Ser 131	-	expression tag
Gly 132	-	expression tag
Arg 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127981.7
Non-Polymers*	Number of molecules	2
	Total formula weight	1012.4
All*	Total formula weight	128994.1

*Water molecules are not included.