5W96
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![BU of 5w96 by Molmil](/molmil-images/mine/5w96) | Solution structure of phage derived peptide inhibitor of frizzled 7 receptor | 分子名称: | Fz7 binding peptide | 著者 | Nile, A.H, de Sousa e Melo, F, Mukund, S, Piskol, R, Hansen, S, Zhou, L, Zhang, Y, Fu, Y, Gogol, E.B, Komuves, L.G, Modrusan, Z, Angers, S, Franke, Y, Koth, C, Fairbrother, W.J, Wang, W, de Sauvage, F.J, Hannoush, R.N. | 登録日 | 2017-06-22 | 公開日 | 2018-04-18 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat. Chem. Biol., 14, 2018
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5TJI
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![BU of 5tji by Molmil](/molmil-images/mine/5tji) | Ca2+ bound aplysia Slo1 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel | 著者 | MacKinnon, R, Tao, X, Hite, R.K. | 登録日 | 2016-10-04 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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8BCY
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![BU of 8bcy by Molmil](/molmil-images/mine/8bcy) | HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 13 | 分子名称: | 9-[2-(3,4-dichlorophenyl)ethyl]-2-(3-hydroxyphenyl)-8-oxidanylidene-7~{H}-purine-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Pala, D, Mazzucato, R, Capelli, A.M, Rancati, F, Biagetti, M. | 登録日 | 2022-10-17 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3K delta inhibitors. Eur.J.Med.Chem., 254, 2023
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5T6K
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![BU of 5t6k by Molmil](/molmil-images/mine/5t6k) | Crystal Structure of TgCDPK1 From Toxoplasma Gondii complexed with GW780159X | 分子名称: | 4-(3-chlorophenyl)-5-(1,5-naphthyridin-2-yl)-1,3-thiazol-2-amine, Calmodulin-domain protein kinase 1, UNKNOWN ATOM OR ION | 著者 | Jiang, D.Q, Tempel, W, Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lovato, D.V, Osman, K.T, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-01 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of CDPK1 from toxoplasma gondii complexed with SGC-1-19 to be published
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8BV2
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8BPB
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![BU of 8bpb by Molmil](/molmil-images/mine/8bpb) | Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom | 分子名称: | ACETATE ION, CALCIUM ION, Histone deacetylase 2, ... | 著者 | Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. | 登録日 | 2022-11-16 | 公開日 | 2023-05-10 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
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5WUF
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![BU of 5wuf by Molmil](/molmil-images/mine/5wuf) | Structural basis for conductance through TRIC cation channels | 分子名称: | CADMIUM ION, Putative membrane protein | 著者 | Mao, Y, Gao, F, Su, M, Wang, X.H, Zeng, Y, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2016-12-17 | 公開日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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8BW9
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5T9S
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![BU of 5t9s by Molmil](/molmil-images/mine/5t9s) | Structure of rabbit RyR1 (Ca2+-only dataset, class 4) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | 著者 | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | 登録日 | 2016-09-09 | 公開日 | 2016-10-12 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
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5TB1
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![BU of 5tb1 by Molmil](/molmil-images/mine/5tb1) | Structure of rabbit RyR1 (EGTA-only dataset, class 1) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION | 著者 | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | 登録日 | 2016-09-10 | 公開日 | 2016-10-12 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
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8BBJ
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8BAN
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8BAV
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5T8D
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![BU of 5t8d by Molmil](/molmil-images/mine/5t8d) | Engineered variant of I-OnuI meganuclease targeting the HIV integrase gene; harbors 47 point mutations relative to wild-type I-OnuI | 分子名称: | CALCIUM ION, DNA (26-MER), I-OnuI_e-vHIVInt_v2 | 著者 | Stoddard, B.L, Werther, R, Lambert, A.R. | 登録日 | 2016-09-07 | 公開日 | 2017-05-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses. Protein Eng.Des.Sel., 30, 2017
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8B9Q
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![BU of 8b9q by Molmil](/molmil-images/mine/8b9q) | Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease | 分子名称: | Amyloid-beta A4 protein, COPPER (II) ION | 著者 | Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H. | 登録日 | 2022-10-06 | 公開日 | 2023-02-08 | 最終更新日 | 2024-06-05 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease. Jacs Au, 2, 2022
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1MY1
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5T9M
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![BU of 5t9m by Molmil](/molmil-images/mine/5t9m) | Structure of rabbit RyR1 (Ca2+-only dataset, class 1) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | 著者 | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | 登録日 | 2016-09-09 | 公開日 | 2016-10-12 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
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8BWA
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![BU of 8bwa by Molmil](/molmil-images/mine/8bwa) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum | 分子名称: | PLATINUM (II) ION, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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5TAY
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![BU of 5tay by Molmil](/molmil-images/mine/5tay) | Structure of rabbit RyR1 (ryanodine dataset, class 2) | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | 著者 | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | 登録日 | 2016-09-10 | 公開日 | 2016-10-12 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
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8BWI
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![BU of 8bwi by Molmil](/molmil-images/mine/8bwi) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2 | 分子名称: | Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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8BWL
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![BU of 8bwl by Molmil](/molmil-images/mine/8bwl) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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5TCM
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![BU of 5tcm by Molmil](/molmil-images/mine/5tcm) | First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536 | 分子名称: | 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Uncharacterized protein | 著者 | Lin, Y.H, Hou, C.F.D, Loppnau, P, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-15 | 公開日 | 2016-10-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536 To be published
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8BWM
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![BU of 8bwm by Molmil](/molmil-images/mine/8bwm) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4042 eV) | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-07 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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5Z99
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8BWD
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![BU of 8bwd by Molmil](/molmil-images/mine/8bwd) | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 1 | 分子名称: | SULFATE ION, Twisted gastrulation protein homolog 1 | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | 登録日 | 2022-12-06 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15, 2024
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