8BCY

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 13

Summary for 8BCY

Entry DOI	10.2210/pdb8bcy/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 9-[2-(3,4-dichlorophenyl)ethyl]-2-(3-hydroxyphenyl)-8-oxidanylidene-7~{H}-purine-6-carboxamide, ... (4 entities in total)
Functional Keywords	pi3kdelta kinase, pi3kdelta kinase inhibitor, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	137924.46
Authors	Pala, D.,Mazzucato, R.,Capelli, A.M.,Rancati, F.,Biagetti, M. (deposition date: 2022-10-17, release date: 2023-05-10)
Primary citation	Mazzucato, R.,Roberti, M.,Capelli, A.M.,Rancati, F.,Biagetti, M.,Fiorelli, C.,Bruno, P.,Ronchi, P.,Bertolini, S.,Corsi, M.,Pala, D. Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3K delta inhibitors. Eur.J.Med.Chem., 254:115331-115331, 2023 Cited by PubMed: 37094451 DOI: 10.1016/j.ejmech.2023.115331 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation