8BV2

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

Summary for 8BV2

Entry DOI	10.2210/pdb8bv2/pdb
Descriptor	Integrase, (2S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-chromen-6-yl)-6-methyl-phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	inhibitors, integrase, hiv-1, viral protein
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	20654.52
Authors	Ruff, M.,Benarous, R. (deposition date: 2022-12-01, release date: 2023-06-07, Last modification date: 2023-07-26)
Primary citation	Bonnard, D.,Le Rouzic, E.,Singer, M.R.,Yu, Z.,Le Strat, F.,Batisse, C.,Batisse, J.,Amadori, C.,Chasset, S.,Pye, V.E.,Emiliani, S.,Ledoussal, B.,Ruff, M.,Moreau, F.,Cherepanov, P.,Benarous, R. Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase. Antimicrob.Agents Chemother., 67:e0046223-e0046223, 2023 Cited by PubMed: 37310224 DOI: 10.1128/aac.00462-23 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation