8BWL

Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium

Summary for 8BWL

• Entry DOI: 10.2210/pdb8bwl/pdb
• Descriptor: Growth/differentiation factor 5, Twisted gastrulation protein homolog 1, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: twisted gastrulation protein homolog 1 (twsg1), growth differentiation factor 5 (gdf5), transforming growth factor beta (tgf-beta) signalling pathway, extracellular protein., signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 42619.46

Authors

Malinauskas, T.,Rudolf, A.F.,Moore, G.,Eggington, H.,Belnoue-Davis, H.,El Omari, K.,Woolley, R.E.,Griffiths, S.C.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.,Siebold, C. (deposition date: 2022-12-06, release date: 2024-06-19)

• Primary citation: Malinauskas, T.,Moore, G.,Rudolf, A.F.,Eggington, H.,Belnoue-Davis, H.L.,El Omari, K.,Griffiths, S.C.,Woolley, R.E.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.L.,Siebold, C.; Molecular mechanism of BMP signal control by Twisted gastrulation.; Nat Commun, 15:4976-4976, 2024; PubMed: 38862520; DOI: 10.1038/s41467-024-49065-8

Experimental method

X-RAY DIFFRACTION (1.96 Å)