8BPB

Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom

Summary for 8BPB

• Entry DOI: 10.2210/pdb8bpb/pdb
• EMDB information: 16148
• Descriptor: Isoform 2 of Paired amphipathic helix protein Sin3b, Histone deacetylase 2, PHD finger protein 12, ... (7 entities in total)
• Functional Keywords: hdac, chromatin, cell cycle, transcription, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 226582.77

Authors

Wan, M.S.M.,Muhammad, R.,Koliopolous, M.G.,Alfieri, C. (deposition date: 2022-11-16, release date: 2023-05-10, Last modification date: 2024-03-27)

• Primary citation: Wan, M.S.M.,Muhammad, R.,Koliopoulos, M.G.,Roumeliotis, T.I.,Choudhary, J.S.,Alfieri, C.; Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.; Nat Commun, 14:2556-2556, 2023; PubMed: 37137925; DOI: 10.1038/s41467-023-38276-0

Experimental method

ELECTRON MICROSCOPY (2.8 Å)