1AYZ
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![BU of 1ayz by Molmil](/molmil-images/mine/1ayz) | |
3BJY
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![BU of 3bjy by Molmil](/molmil-images/mine/3bjy) | Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DAP*DTP*DCP*DCP*DTP*DCP*DCP*DCP*DCP*DTP*DAP*(DOC))-3'), DNA (5'-D(*DTP*DAP*DAP*(P)P*DGP*DTP*DAP*DGP*DGP*DGP*DGP*DAP*DGP*DGP*DAP*DT)-3'), ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2007-12-05 | Release date: | 2008-10-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase Structure, 16, 2008
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5L2X
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![BU of 5l2x by Molmil](/molmil-images/mine/5l2x) | Crystal structure of human PrimPol ternary complex | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*GP*GP*TP*AP*GP*CP*(DDG))-3'), ... | Authors: | Rechkoblit, O, Gupta, Y.K, Malik, R, Rajashankar, K.R, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2016-08-02 | Release date: | 2016-11-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Sci Adv, 2, 2016
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4EEY
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![BU of 4eey by Molmil](/molmil-images/mine/4eey) | Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ... | Authors: | Ummat, A, Rechkoblit, O, Jain, R, Choudhury, J.R, Johnson, R.E, Silverstein, T.D, Buku, A, Lone, S, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2012-03-28 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy. Nat.Struct.Mol.Biol., 19, 2012
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4PTF
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![BU of 4ptf by Molmil](/molmil-images/mine/4ptf) | Ternary crystal structure of yeast DNA polymerase epsilon with template G | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*(DOC))-3', ... | Authors: | Jain, R, Rajashankar, K.R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2014-03-10 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.809 Å) | Cite: | Crystal Structure of Yeast DNA Polymerase epsilon Catalytic Domain. Plos One, 9, 2014
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2OH2
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![BU of 2oh2 by Molmil](/molmil-images/mine/2oh2) | Ternary Complex of Human DNA Polymerase | Descriptor: | 5'-D(*GP*GP*G*GP*GP*AP*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*TP*T*CP*CP*AP*GP*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase kappa, ... | Authors: | Lone, S, Townson, S.A, Uljon, S.N, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2007-01-09 | Release date: | 2007-02-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Ternary complex of the catalytic core of human DNA polymerase Kappa with DNA and dTT To be Published
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3H40
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![BU of 3h40 by Molmil](/molmil-images/mine/3h40) | Binary complex of human DNA polymerase iota with template U/T | Descriptor: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | Authors: | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2009-04-17 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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3H4D
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![BU of 3h4d by Molmil](/molmil-images/mine/3h4d) | Ternary complex of human DNA polymerase iota with template U/T and incoming dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC)), 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T), ... | Authors: | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2009-04-18 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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3H4B
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![BU of 3h4b by Molmil](/molmil-images/mine/3h4b) | Ternary complex of human DNA polymerase iota with template U/T and incoming dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2009-04-18 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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3PZP
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![BU of 3pzp by Molmil](/molmil-images/mine/3pzp) | Human DNA polymerase kappa extending opposite a cis-syn thymine dimer | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*CP*A)-3', 5'-D(*TP*TP*CP*CP*(TTD)P*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Vasquez-Del Carpio, R, Silverstein, T.D, Lone, S, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2010-12-14 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.336 Å) | Cite: | Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer. J.Mol.Biol., 408, 2011
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1S97
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![BU of 1s97 by Molmil](/molmil-images/mine/1s97) | DPO4 with GT mismatch | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*G)-3', 5'-D(*T*TP*CP*AP*GP*TP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Trincao, J, Johnson, R.E, Wolfle, W.T, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-02-03 | Release date: | 2004-04-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Dpo4 is hindered in extending a G.T mismatch by a reverse wobble Nat.Struct.Mol.Biol., 11, 2004
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1S9F
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![BU of 1s9f by Molmil](/molmil-images/mine/1s9f) | DPO with AT matched | Descriptor: | 2',3'-DIDEOXYCYTOSINE-5'-DIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*A)-3', 5'-D(*T*TP*CP*AP*GP*TP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Trincao, J, Johnson, R.E, Wolfle, W.T, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-02-04 | Release date: | 2005-02-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dpo4 is hindered in extending a G.T mismatch by a reverse wobble Nat.Struct.Mol.Biol., 11, 2004
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3TQ1
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![BU of 3tq1 by Molmil](/molmil-images/mine/3tq1) | Human DNA Polymerase eta in binary complex with DNA | Descriptor: | DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta | Authors: | Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2011-09-08 | Release date: | 2012-02-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.556 Å) | Cite: | Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis. J.Mol.Biol., 415, 2012
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3MFH
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![BU of 3mfh by Molmil](/molmil-images/mine/3mfh) | DNA Polymerase Eta in Complex With Undamaged DNA | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*TP*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... | Authors: | Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2010-04-02 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
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3MFI
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![BU of 3mfi by Molmil](/molmil-images/mine/3mfi) | DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*(TTD)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... | Authors: | Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2010-04-02 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
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1T3N
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![BU of 1t3n by Molmil](/molmil-images/mine/1t3n) | Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP | Descriptor: | MAGNESIUM ION, Primer DNA strand, THYMIDINE-5'-TRIPHOSPHATE, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-04-27 | Release date: | 2004-07-20 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature, 430, 2004
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1T94
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![BU of 1t94 by Molmil](/molmil-images/mine/1t94) | Crystal structure of the catalytic core of human DNA polymerase kappa | Descriptor: | polymerase (DNA directed) kappa | Authors: | Uljon, S.N, Johnson, R.E, Edwards, T.A, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-05-14 | Release date: | 2004-08-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the catalytic core of human DNA polymerase kappa. STRUCTURE, 12, 2004
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1JIH
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![BU of 1jih by Molmil](/molmil-images/mine/1jih) | Yeast DNA Polymerase ETA | Descriptor: | DNA Polymerase ETA | Authors: | Trincao, J, Johnson, R.E, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2001-07-02 | Release date: | 2002-01-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis Mol.Cell, 8, 2001
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2DPJ
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![BU of 2dpj by Molmil](/molmil-images/mine/2dpj) | structure of hPoli with DNA and dTTP | Descriptor: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-05-12 | Release date: | 2006-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat.Struct.Mol.Biol., 13, 2006
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2ALZ
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![BU of 2alz by Molmil](/molmil-images/mine/2alz) | Ternary Complex of hPoli with DNA and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2005-08-08 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human DNA Polymerase iota Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair. Structure, 13, 2005
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2AQ4
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![BU of 2aq4 by Molmil](/molmil-images/mine/2aq4) | Ternary complex of the catalytic core of REV1 with DNA and dCTP. | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*C)-3', 5'-D(*TP*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2005-08-17 | Release date: | 2005-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science, 309, 2005
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2DPI
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![BU of 2dpi by Molmil](/molmil-images/mine/2dpi) | Ternary complex of hPoli with DNA and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(EDA)P*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-05-12 | Release date: | 2006-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat.Struct.Mol.Biol., 13, 2006
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2FLP
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![BU of 2flp by Molmil](/molmil-images/mine/2flp) | Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-01-06 | Release date: | 2006-12-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure, 14, 2006
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2FLL
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![BU of 2fll by Molmil](/molmil-images/mine/2fll) | Ternary complex of human DNA polymerase iota with DNA and dTTP | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-01-06 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure, 14, 2006
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2FLN
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![BU of 2fln by Molmil](/molmil-images/mine/2fln) | binary complex of catalytic core of human DNA polymerase iota with DNA (template A) | Descriptor: | DNA polymerase iota, DNA primer strand, DNA template strand | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2006-01-06 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure, 14, 2006
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