Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP

Summary for 1T3N

DescriptorTemplate DNA strand, Primer DNA strand, polymerase (DNA directed) iota, ... (6 entities in total)
Functional Keywordsprotein, dna, dttp, replication-dna complex, replication/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q9UNA4
Total number of polymer chains4
Total molecular weight96507.63
Nair, D.T.,Johnson, R.E.,Prakash, S.,Prakash, L.,Aggarwal, A.K. (deposition date: 2004-04-27, release date: 2004-07-20, Last modification date: 2018-04-18)
Primary citation
Nair, D.T.,Johnson, R.E.,Prakash, S.,Prakash, L.,Aggarwal, A.K.
Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
Nature, 430:377-380, 2004
PubMed: 15254543 (PDB entries with the same primary citation)
DOI: 10.1038/nature02692
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27651 5.7% 10.4% 23.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23