1T3N
Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006281 | biological_process | DNA repair |
| B | 0003684 | molecular_function | damaged DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0006281 | biological_process | DNA repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 869 |
| Chain | Residue |
| B | ASP454 |
| B | LEU455 |
| B | ASP546 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP B 868 |
| Chain | Residue |
| B | VAL484 |
| B | THR485 |
| B | TYR488 |
| B | ARG491 |
| B | LEU498 |
| B | ASP546 |
| B | LYS634 |
| P | DOC13 |
| T | DA5 |
| T | DG6 |
| B | ASP454 |
| B | LEU455 |
| B | ASP456 |
| B | CYS457 |
| B | PHE458 |
| B | TYR459 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 426 |
| Details | Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 358 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
