2FLP

Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G)

Summary for 2FLP

Related1T3N 2ALZ 2FLN 2FLL
DescriptorDNA template strand, DNA primer strand, DNA polymerase iota, ... (4 entities in total)
Functional Keywordsdna polymerase, lesion bypass, y-family, binary complex, template g, replication-dna complex, replication/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9UNA4
Total number of polymer chains3
Total molecular weight52474.94
Authors
Nair, D.T.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. (deposition date: 2006-01-06, release date: 2006-12-05, Last modification date: 2011-07-13)
Primary citation
Nair, D.T.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K.
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14:749-755, 2006
PubMed: 16615915 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2006.01.010
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274364.7%12.5%20.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2flp
no rotation
Molmil generated image of 2flp
rotated about x axis by 90°
Molmil generated image of 2flp
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2flp
no rotation
Molmil generated image of 2flp
rotated about x axis by 90°
Molmil generated image of 2flp
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2flp.pdb1.gz [132.27 KB])
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