3MFI

DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer

Summary for 3MFI

• Entry DOI: 10.2210/pdb3mfi/pdb
• Related: 1JIH 3MFH
• Descriptor: DNA polymerase eta, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*(TTD)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... (7 entities in total)
• Functional Keywords: dna damage, dna repair, dna replication, dna synthesis, nucleus, dna-binding, magnesium, metal-binding, dna-directed dna polymerase, mutator protein, nucleotidyltransferase, dna polymerase eta, protein-dna complex, thymidine dimer, cpd, uv-damage, transferase-dna complex, transferase/dna
• Biological source: Saccharomyces cerevisiae (yeast); More
• Cellular location: Nucleus : Q04049
• Total number of polymer chains: 3
• Total formula weight: 67777.70

Authors

Silverstein, T.D.,Johnson, R.E.,Jain, R.,Prakash, L.,Prakash, S.,Aggarwal, A.K. (deposition date: 2010-04-02, release date: 2010-06-23, Last modification date: 2023-09-06)

• Primary citation: Silverstein, T.D.,Johnson, R.E.,Jain, R.,Prakash, L.,Prakash, S.,Aggarwal, A.K.; Structural basis for the suppression of skin cancers by DNA polymerase eta.; Nature, 465:1039-1043, 2010; PubMed: 20577207; DOI: 10.1038/nature09104

Experimental method

X-RAY DIFFRACTION (1.76 Å)