7D77
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![BU of 7d77 by Molmil](/molmil-images/mine/7d77) | Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex | Descriptor: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | Authors: | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | Deposit date: | 2020-10-03 | Release date: | 2021-02-03 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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7EPT
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![BU of 7ept by Molmil](/molmil-images/mine/7ept) | Structural basis for the tethered peptide activation of adhesion GPCRs | Descriptor: | Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ping, Y.-Q, Xiao, P, Yang, F, Zhao, R.-J, Guo, S.-C, Yan, X, Wu, X, Liebscher, I, Xu, H.E, Sun, J.-P. | Deposit date: | 2021-04-27 | Release date: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604, 2022
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7EQ1
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![BU of 7eq1 by Molmil](/molmil-images/mine/7eq1) | GPR114-Gs-scFv16 complex | Descriptor: | Adhesion G-protein coupled receptor G5, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ping, Y. | Deposit date: | 2021-04-28 | Release date: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604, 2022
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7D76
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![BU of 7d76 by Molmil](/molmil-images/mine/7d76) | Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex | Descriptor: | (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | Authors: | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | Deposit date: | 2020-10-03 | Release date: | 2021-02-03 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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1NG2
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![BU of 1ng2 by Molmil](/molmil-images/mine/1ng2) | Structure of autoinhibited p47phox | Descriptor: | Neutrophil cytosolic factor 1 | Authors: | Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K. | Deposit date: | 2002-12-16 | Release date: | 2003-05-20 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of phosphorylation-induced activation of the NADPH oxidase Cell(Cambridge,Mass.), 113, 2003
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1OV3
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![BU of 1ov3 by Molmil](/molmil-images/mine/1ov3) | Structure of the p22phox-p47phox complex | Descriptor: | Flavocytochrome b558 alpha polypeptide, Neutrophil cytosol factor 1 | Authors: | Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K. | Deposit date: | 2003-03-25 | Release date: | 2003-05-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis of phosphorylation-induced activation of the NADPH oxidase Cell(Cambridge,Mass.), 113, 2003
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5ZWK
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![BU of 5zwk by Molmil](/molmil-images/mine/5zwk) | Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with fructose-1,6-bisphophate and AMP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | Authors: | Yunyuan, H, Zeyuan, G, Junjie, Y, Ping, Y, Jian, W. | Deposit date: | 2018-05-15 | Release date: | 2019-05-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Location of FBPase catalytic metal binding site: a combined experimental and theoretical study To Be Published
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7CFN
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![BU of 7cfn by Molmil](/molmil-images/mine/7cfn) | Cryo-EM structure of the INT-777-bound GPBAR-Gs complex | Descriptor: | (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | Authors: | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | Deposit date: | 2020-06-27 | Release date: | 2020-09-09 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 2020
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7CFM
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![BU of 7cfm by Molmil](/molmil-images/mine/7cfm) | Cryo-EM structure of the P395-bound GPBAR-Gs complex | Descriptor: | 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | Authors: | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | Deposit date: | 2020-06-27 | Release date: | 2020-09-09 | Last modified: | 2020-12-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 2020
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2AK5
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![BU of 2ak5 by Molmil](/molmil-images/mine/2ak5) | beta PIX-SH3 complexed with a Cbl-b peptide | Descriptor: | 8-residue peptide from a signal transduction protein CBL-B, Rho guanine nucleotide exchange factor 7 | Authors: | Jozic, D, Cardenes, N, Deribe, Y.L, Moncalian, G, Hoeller, D, Groemping, Y, Dikic, I, Rittinger, K, Bravo, J. | Deposit date: | 2005-08-03 | Release date: | 2005-10-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Cbl promotes clustering of endocytic adaptor proteins. Nat.Struct.Mol.Biol., 12, 2005
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2JXC
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![BU of 2jxc by Molmil](/molmil-images/mine/2jxc) | Structure of the EPS15-EH2 Stonin2 Complex | Descriptor: | CALCIUM ION, Epidermal growth factor receptor substrate 15, Stonin-2 | Authors: | Rumpf, J, Simon, B, Jung, N, Maritzen, T, Haucke, V, Sattler, M, Groemping, Y. | Deposit date: | 2007-11-12 | Release date: | 2008-01-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. Embo J., 27, 2008
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5A37
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![BU of 5a37 by Molmil](/molmil-images/mine/5a37) | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle. | Descriptor: | HUMAN ALPHA-ACTININ-2 | Authors: | Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M. | Deposit date: | 2015-05-27 | Release date: | 2016-06-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473, 2016
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5A4B
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![BU of 5a4b by Molmil](/molmil-images/mine/5a4b) | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle. | Descriptor: | HUMAN ALPHA-ACTININ-2 | Authors: | Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M. | Deposit date: | 2015-06-05 | Release date: | 2016-06-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473, 2016
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5A36
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![BU of 5a36 by Molmil](/molmil-images/mine/5a36) | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle. | Descriptor: | ALPHA-ACTININ-2 | Authors: | Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M. | Deposit date: | 2015-05-27 | Release date: | 2016-06-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473, 2016
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5A38
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![BU of 5a38 by Molmil](/molmil-images/mine/5a38) | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle. | Descriptor: | ALPHA-ACTININ-2 | Authors: | Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M. | Deposit date: | 2015-05-27 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473, 2016
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3RRT
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3RRR
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![BU of 3rrr by Molmil](/molmil-images/mine/3rrr) | Structure of the RSV F protein in the post-fusion conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | Authors: | McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D. | Deposit date: | 2011-04-30 | Release date: | 2011-06-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.821 Å) | Cite: | Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes. J.Virol., 85, 2011
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4C46
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![BU of 4c46 by Molmil](/molmil-images/mine/4c46) | ANDREI-N-LVPAS fused to GCN4 adaptors | Descriptor: | BROMIDE ION, GENERAL CONTROL PROTEIN GCN4 | Authors: | Albrecht, R, Alva, V, Ammelburg, M, Baer, K, Basina, E, Boichenko, I, Bonhoeffer, F, Braun, V, Chaubey, M, Chauhan, N, Chellamuthu, V.R, Coles, M, Deiss, S, Ewers, C.P, Forouzan, D, Fuchs, A, Groemping, Y, Hartmann, M.D, Hernandez Alvarez, B, Jeganantham, A, Kalev, I, Koenninger, U, Koiwai, K, Kopec, K.O, Korycinski, M, Laudenbach, B, Lehmann, K, Leo, J.C, Linke, D, Marialke, J, Martin, J, Mechelke, M, Michalik, M, Noll, A, Patzer, S.I, Scharfenberg, F, Schueckel, M, Shahid, S.A, Sulz, E, Ursinus, A, Wuertenberger, S, Zhu, H. | Deposit date: | 2013-08-30 | Release date: | 2013-09-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Your Personalized Protein Structure: Andrei N. Lupas Fused to GCN4 Adaptors. J.Struct.Biol., 186, 2014
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5V35
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![BU of 5v35 by Molmil](/molmil-images/mine/5v35) | Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2017-03-06 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9K
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5U9A
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![BU of 5u9a by Molmil](/molmil-images/mine/5u9a) | |
5U9J
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![BU of 5u9j by Molmil](/molmil-images/mine/5u9j) | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with geranyl geranyl pyrophoshate | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), GERAN-8-YL GERAN, ISOPROPYL ALCOHOL, ... | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2016-12-16 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9I
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![BU of 5u9i by Molmil](/molmil-images/mine/5u9i) | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2016-12-16 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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