5A4B

Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.

Summary for 5A4B

Entry DOI	10.2210/pdb5a4b/pdb
Descriptor	HUMAN ALPHA-ACTININ-2 (2 entities in total)
Functional Keywords	structural protein, calponin homology domains
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, myofibril, sarcomere, Z line : P35609
Total number of polymer chains	2
Total formula weight	56925.50
Authors	Haywood, N.J.,Wolny, M.,Trinh, C.H.,Shuping, Y.,Edwards, T.A.,Peckham, M. (deposition date: 2015-06-05, release date: 2016-06-22, Last modification date: 2016-08-24)
Primary citation	Haywood, N.,Wolny, M.,Rogers, B.,Trinh, C.H.,Shuping, Y.,Edwards, T.A.,Peckham, M. Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Biochem.J., 473:2485-, 2016 Cited by PubMed: 27287556 DOI: 10.1042/BCJ20160421 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation