5A4B

Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QRkTFTAWCN

Chain	Residue	Details
A	GLN40-ASN49

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site_id	PS00020
Number of Residues	25
Details	ACTININ_2 Actinin-type actin-binding domain signature 2. LvSIGTeEIvDgnvkMtLGMIWtII

Chain	Residue	Details
A	LEU114-ILE138

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	208
Details	Domain: {"description":"Calponin-homology (CH) 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	212
Details	Domain: {"description":"Calponin-homology (CH) 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9JI91","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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