5A37

Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.

Summary for 5A37

• Entry DOI: 10.2210/pdb5a37/pdb
• Related: 5A36 5A38
• Descriptor: HUMAN ALPHA-ACTININ-2 (2 entities in total)
• Functional Keywords: actin-binding protein, human alpha-actinin-2, calponin homology domains
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, myofibril, sarcomere, Z line : P35609
• Total number of polymer chains: 2
• Total formula weight: 57257.94

Authors

Haywood, N.J.,Wolny, M.,Trinh, C.H.,Shuping, Y.,Edwards, T.A.,Peckham, M. (deposition date: 2015-05-27, release date: 2016-06-22, Last modification date: 2016-08-24)

• Primary citation: Haywood, N.,Wolny, M.,Rogers, B.,Trinh, C.H.,Shuping, Y.,Edwards, T.A.,Peckham, M.; Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.; Biochem.J., 473:2485-, 2016; PubMed: 27287556; DOI: 10.1042/BCJ20160421

Experimental method

X-RAY DIFFRACTION (1.88 Å)