5A37

Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	HUMAN ALPHA-ACTININ-2	polymer	250	28629.0	2	UniProt (P35609) Pfam (PF00307) In PDB	HOMO SAPIENS (HUMAN)	ALPHA-ACTININ SKELETAL MUSCLE ISOFORM 2, F-ACTIN CROSS-LINK ING PROTEIN, HUMAN ALPHA-ACTININ-2
2		water	water		18.0	307	Chemie (HOH)

Sequence modifications

A, B: 19 - 266 (UniProt: P35609)

PDB	External Database	Details
Gly 17	-	expression tag
Pro 18	-	expression tag
Val 111	Gly 111	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57257.9
All*	Total formula weight	57257.9

*Water molecules are not included.