2KBS
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![BU of 2kbs by Molmil](/molmil-images/mine/2kbs) | Solution structure of harmonin PDZ2 in complex with the carboxyl tail peptide of cadherin23 | Descriptor: | Harmonin, octameric peptide from Cadherin-23 | Authors: | Pan, L, Yan, J, Wu, L, Zhang, M. | Deposit date: | 2008-12-05 | Release date: | 2009-03-31 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23 Proc.Natl.Acad.Sci.USA, 106, 2009
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2KBR
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![BU of 2kbr by Molmil](/molmil-images/mine/2kbr) | Solution structure of harmonin N terminal domain in complex with a internal peptide of cadherin23 | Descriptor: | 18-meric peptide from Cadherin-23, Harmonin | Authors: | Pan, L, Yan, J, Wu, L, Zhang, M. | Deposit date: | 2008-12-05 | Release date: | 2009-03-31 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23 Proc.Natl.Acad.Sci.USA, 106, 2009
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2L7T
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2LSR
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![BU of 2lsr by Molmil](/molmil-images/mine/2lsr) | Solution structure of harmonin N terminal domain in complex with a exon68 encoded peptide of cadherin23 | Descriptor: | Harmonin, peptide from Cadherin-23 | Authors: | Pan, L, Wu, L, Zhang, C, Zhang, M. | Deposit date: | 2012-05-04 | Release date: | 2012-08-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. J.Biol.Chem., 287, 2012
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3K1R
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![BU of 3k1r by Molmil](/molmil-images/mine/3k1r) | |
5YT6
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5XGV
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3CYY
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6RLV
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![BU of 6rlv by Molmil](/molmil-images/mine/6rlv) | Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine | Descriptor: | 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, GLYCEROL, MALONATE ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2019-05-02 | Release date: | 2020-01-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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6S30
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![BU of 6s30 by Molmil](/molmil-images/mine/6s30) | Crystal Structure of Seryl-tRNA Synthetase from Klebsiella pneumoniae | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Serine--tRNA ligase | Authors: | Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V. | Deposit date: | 2019-06-23 | Release date: | 2020-01-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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7YP8
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![BU of 7yp8 by Molmil](/molmil-images/mine/7yp8) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Leucyl-sulfamoyl 3-deazaadenosine | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2022-08-02 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The essential role of a structured water in base recognition of Class II aminoacyl-tRNA synthetases To be published
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5BTU
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5BU3
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![BU of 5bu3 by Molmil](/molmil-images/mine/5bu3) | Crystal Structure of Diels-Alderase PyrI4 in complex with its product | Descriptor: | (4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione, GLYCEROL, PyrI4 | Authors: | Pan, L, Guo, Y, Liu, J. | Deposit date: | 2015-06-03 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol, 23, 2016
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2MXP
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7X9P
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![BU of 7x9p by Molmil](/molmil-images/mine/7x9p) | Crystal structure of human STING complexed with compound BSP17 | Descriptor: | 4-[6-methoxy-5-[3-[[6-methoxy-2-(4-oxidanyl-4-oxidanylidene-butanoyl)-1-benzoselenophen-5-yl]oxy]propoxy]-1-benzoselenophen-2-yl]-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein | Authors: | Pan, L, Guan, X, Feng, X, Li, Z, Bian, J. | Deposit date: | 2022-03-15 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery of Selenium-containing STING agonists as orally available anti tumor agents To be published
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2PKU
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![BU of 2pku by Molmil](/molmil-images/mine/2pku) | Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 | Descriptor: | PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE) | Authors: | Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M. | Deposit date: | 2007-04-18 | Release date: | 2007-11-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes Embo J., 26, 2007
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7X9Q
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![BU of 7x9q by Molmil](/molmil-images/mine/7x9q) | Crystal structure of human STING complexed with compound BSP16 | Descriptor: | (2R)-4-(5,6-dimethoxy-1-benzoselenophen-2-yl)-2-ethyl-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein | Authors: | Pan, L, Guan, X, Feng, X, Li, Z, Bian, J. | Deposit date: | 2022-03-15 | Release date: | 2022-09-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents. J.Med.Chem., 65, 2022
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5F5L
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5F5N
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8K7X
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![BU of 8k7x by Molmil](/molmil-images/mine/8k7x) | Crystal structure of GH146 beta-L-arabinofuranosidase Bll3HypBA1 (amino acids 380-1223) in complex with Tris | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... | Authors: | Pan, L, Maruyama, S, Miyake, M, Fujita, K, Fushinobu, S. | Deposit date: | 2023-07-27 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Bifidobacterial GH146 beta-L-arabinofuranosidase for the removal of beta 1,3-L-arabinofuranosides on plant glycans. Appl.Microbiol.Biotechnol., 108, 2024
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6YKQ
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![BU of 6ykq by Molmil](/molmil-images/mine/6ykq) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKN
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![BU of 6ykn by Molmil](/molmil-images/mine/6ykn) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKX
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![BU of 6ykx by Molmil](/molmil-images/mine/6ykx) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11j | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKW
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![BU of 6ykw by Molmil](/molmil-images/mine/6ykw) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11h | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKK
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![BU of 6ykk by Molmil](/molmil-images/mine/6ykk) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 15 | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.236 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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