7A0P

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11i

Summary for 7A0P

Entry DOI	10.2210/pdb7a0p/pdb
Related	6YKK 6YKL 6YKN 6YKQ 6YKS 6YKT 6YKU 6YKV 6YKW 6YKX
Descriptor	Leucine--tRNA ligase, 1,2-ETHANEDIOL, ZINC ION, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, rossmann fold, trna synthetase, ligase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	99043.93
Authors	Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-08-10, release date: 2020-12-02, Last modification date: 2024-01-31)
Primary citation	De Ruysscher, D.,Pang, L.,Lenders, S.M.G.,Cappoen, D.,Cos, P.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211:113021-113021, 2021 Cited by PubMed: 33248851 DOI: 10.1016/j.ejmech.2020.113021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation