3CYY

The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide

Summary for 3CYY

Entry DOI	10.2210/pdb3cyy/pdb
Descriptor	Tight junction protein ZO-1, peptide from Gap junction alpha-1 protein (3 entities in total)
Functional Keywords	protein-ligand complex, cell junction, membrane, phosphoprotein, sh3 domain, tight junction, gap junction, transmembrane, peptide binding protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side: Q07157 Cell membrane; Multi-pass membrane protein: P08050
Total number of polymer chains	4
Total formula weight	22529.80
Authors	Pan, L.,Zhang, M. (deposition date: 2008-04-27, release date: 2008-09-23, Last modification date: 2023-11-01)
Primary citation	Chen, J.,Pan, L.,Wei, Z.,Zhao, Y.,Zhang, M. Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites Embo J., 27:2113-2123, 2008 Cited by PubMed: 18636092 DOI: 10.1038/emboj.2008.138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation