7OT3

Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3b

Summary for 7OT3

• Entry DOI: 10.2210/pdb7ot3/pdb
• Related: 7OT2
• Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, ~{N}-[(2-chlorophenyl)methyl]-3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide, ... (6 entities in total)
• Functional Keywords: beta barrel, trna synthetase, protein-inhibitor complex, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 117660.83

Authors

Pang, L.,Zitko, J.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2021-06-09, release date: 2021-07-28, Last modification date: 2024-01-31)

• Primary citation: Pang, L.,Weeks, S.D.,Juhas, M.,Strelkov, S.V.,Zitko, J.,Van Aerschot, A.; Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.; Int J Mol Sci, 22:-, 2021; PubMed: 34360555; DOI: 10.3390/ijms22157793

Experimental method

X-RAY DIFFRACTION (2.53 Å)