5W21
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![BU of 5w21 by Molmil](/molmil-images/mine/5w21) | Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ... | Authors: | Mohammadi, M. | Deposit date: | 2017-06-05 | Release date: | 2018-01-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature, 553, 2018
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7YSU
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![BU of 7ysu by Molmil](/molmil-images/mine/7ysu) | Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-13 | Release date: | 2023-04-19 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSH
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![BU of 7ysh by Molmil](/molmil-images/mine/7ysh) | Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-12 | Release date: | 2023-04-19 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSW
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![BU of 7ysw by Molmil](/molmil-images/mine/7ysw) | Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-13 | Release date: | 2023-06-14 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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1AGW
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![BU of 1agw by Molmil](/molmil-images/mine/1agw) | |
6PNX
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![BU of 6pnx by Molmil](/molmil-images/mine/6pnx) | |
2FGI
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![BU of 2fgi by Molmil](/molmil-images/mine/2fgi) | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074 | Descriptor: | 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA, PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1) | Authors: | Mohammadi, M, Froum, S, Hamby, J.M, Schroeder, M, Panek, R.L, Lu, G.H, Eliseenkova, A.V, Green, D, Schlessinger, J, Hubbard, S.R. | Deposit date: | 1998-09-15 | Release date: | 1999-09-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J., 17, 1998
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3HBW
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![BU of 3hbw by Molmil](/molmil-images/mine/3hbw) | |
1FGI
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![BU of 1fgi by Molmil](/molmil-images/mine/1fgi) | |
2FDB
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![BU of 2fdb by Molmil](/molmil-images/mine/2fdb) | |
1FGK
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![BU of 1fgk by Molmil](/molmil-images/mine/1fgk) | |
5UHN
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![BU of 5uhn by Molmil](/molmil-images/mine/5uhn) | |
5UGX
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![BU of 5ugx by Molmil](/molmil-images/mine/5ugx) | |
5UGL
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![BU of 5ugl by Molmil](/molmil-images/mine/5ugl) | |
5UI0
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![BU of 5ui0 by Molmil](/molmil-images/mine/5ui0) | |
5W59
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![BU of 5w59 by Molmil](/molmil-images/mine/5w59) | |
2P39
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![BU of 2p39 by Molmil](/molmil-images/mine/2p39) | Crystal structure of human FGF23 | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Fibroblast growth factor 23 | Authors: | Mohammadi, M. | Deposit date: | 2007-03-08 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol.Cell.Biol., 27, 2007
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2P23
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![BU of 2p23 by Molmil](/molmil-images/mine/2p23) | Crystal structure of human FGF19 | Descriptor: | Fibroblast growth factor 19 | Authors: | Mohammadi, M. | Deposit date: | 2007-03-06 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol.Cell.Biol., 27, 2007
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5EG3
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![BU of 5eg3 by Molmil](/molmil-images/mine/5eg3) | Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma) | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ... | Authors: | Huang, Z, Li, X, Mohammadi, M. | Deposit date: | 2015-10-26 | Release date: | 2016-02-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma. Mol.Cell, 61, 2016
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1RY7
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![BU of 1ry7 by Molmil](/molmil-images/mine/1ry7) | Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1 | Descriptor: | Fibroblast growth factor receptor 3, Heparin-binding growth factor 1 | Authors: | Olsen, S.K, Ibrahimi, O.A, Raucci, A, Zhang, F, Eliseenkova, A.V, Yayon, A, Basilico, C, Linhardt, R.J, Schlessinger, J, Mohammadi, M. | Deposit date: | 2003-12-19 | Release date: | 2004-02-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc.Natl.Acad.Sci.Usa, 101, 2004
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3F1R
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![BU of 3f1r by Molmil](/molmil-images/mine/3f1r) | Crystal structure of FGF20 dimer | Descriptor: | Fibroblast growth factor 20, SULFATE ION | Authors: | Kalinina, J, Mohammadi, M. | Deposit date: | 2008-10-28 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix Mol.Cell.Biol., 29, 2009
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1Q1U
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![BU of 1q1u by Molmil](/molmil-images/mine/1q1u) | Crystal structure of human FHF1b (FGF12b) | Descriptor: | SULFATE ION, fibroblast growth factor homologous factor 1 | Authors: | Olsen, S.K, Garbi, M, Zampieri, N, Eliseenkova, A.V, Ornitz, D.M, Goldfarb, M, Mohammadi, M. | Deposit date: | 2003-07-22 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs J.Biol.Chem., 278, 2003
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1NUN
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![BU of 1nun by Molmil](/molmil-images/mine/1nun) | Crystal Structure Analysis of the FGF10-FGFR2b Complex | Descriptor: | Fibroblast growth factor-10, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ... | Authors: | Yeh, B.K, Igarashi, M, Eliseenkova, A.V, Plotnikov, A.N, Sher, I, Ron, D, Aaronson, S.A, Mohammadi, M. | Deposit date: | 2003-01-31 | Release date: | 2003-02-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis by which alternative splicing confers
specificity in fibroblast growth factor receptors. Proc.Natl.Acad.Sci.USA, 100, 2003
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1CVS
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![BU of 1cvs by Molmil](/molmil-images/mine/1cvs) | CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX | Descriptor: | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION | Authors: | Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M. | Deposit date: | 1999-08-24 | Release date: | 2000-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98, 1999
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3OJ2
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![BU of 3oj2 by Molmil](/molmil-images/mine/3oj2) | |