6PNX

Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction

Summary for 6PNX

Entry DOI	10.2210/pdb6pnx/pdb
Descriptor	Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
Functional Keywords	tyrosine kinase, transphosphorylation, asymmetric dimer, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	74290.25
Authors	Mohammadi, M. (deposition date: 2019-07-03, release date: 2020-01-22, Last modification date: 2023-10-11)
Primary citation	Chen, L.,Marsiglia, W.M.,Chen, H.,Katigbak, J.,Erdjument-Bromage, H.,Kemble, D.J.,Fu, L.,Ma, J.,Sun, G.,Zhang, Y.,Liang, G.,Neubert, T.A.,Li, X.,Traaseth, N.J.,Mohammadi, M. Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation. Nat.Chem.Biol., 16:267-277, 2020 Cited by PubMed: 31959966 DOI: 10.1038/s41589-019-0455-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.199 Å)

Structure validation