6PNX
Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 3 | polymer | 324 | 36543.9 | 2 | UniProt (P22607) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-3 |
2 | A, B | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A, B: 451 - 759 (UniProt: P22607)
PDB | External Database | Details |
---|---|---|
Met 436 | - | expression tag |
Gly 437 | - | expression tag |
Ser 438 | - | expression tag |
Ser 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
His 442 | - | expression tag |
His 443 | - | expression tag |
His 444 | - | expression tag |
His 445 | - | expression tag |
Ser 446 | - | expression tag |
Gln 447 | - | expression tag |
Asp 448 | - | expression tag |
Pro 449 | - | expression tag |
Thr 450 | - | expression tag |
Ala 482 | Cys 482 | engineered mutation |
Ser 582 | Cys 582 | engineered mutation |
Glu 669 | Arg 669 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73087.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1202.5 | |
All* | Total formula weight | 74290.3 |