6PNX

Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 3	polymer	324	36543.9	2	UniProt (P22607) Pfam (PF07714)	Homo sapiens (Human)	FGFR-3
2	C, E (A, B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	2	Chemie (ACP)
3	D, F (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	G, H (A, B)	water	water		18.0	249	Chemie (HOH)

Sequence modifications

A, B: 451 - 759 (UniProt: P22607)

PDB	External Database	Details
Met 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag
Ser 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
Ser 446	-	expression tag
Gln 447	-	expression tag
Asp 448	-	expression tag
Pro 449	-	expression tag
Thr 450	-	expression tag
Ala 482	Cys 482	engineered mutation
Ser 582	Cys 582	engineered mutation
Glu 669	Arg 669	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73087.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1202.5
All*	Total formula weight	74290.3

*Water molecules are not included.