5UGX
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation
Summary for 5UGX
Entry DOI | 10.2210/pdb5ugx/pdb |
Related | 5UGL 5UHN 5UI0 |
Descriptor | Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | tyrosine kinase domain, gain-of-function mutations, cell surface atp analog, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75516.45 |
Authors | Mohammadi, M.,Chen, H. (deposition date: 2017-01-10, release date: 2017-02-22, Last modification date: 2023-10-04) |
Primary citation | Chen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife, 6:-, 2017 Cited by PubMed: 28166054DOI: 10.7554/eLife.21137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.349 Å) |
Structure validation
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