5EG3

Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)

Summary for 5EG3

Entry DOI	10.2210/pdb5eg3/pdb
Related	2PSQ 2PVF 2PVY
Descriptor	Fibroblast growth factor receptor 2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	signaling complex, tyrosine kinase domain, sh2 domain, recruitment, phosphorylation, transferase-hydrolase complex, transferase/hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	52019.62
Authors	Huang, Z.,Li, X.,Mohammadi, M. (deposition date: 2015-10-26, release date: 2016-02-03, Last modification date: 2023-11-15)
Primary citation	Huang, Z.,Marsiglia, W.M.,Basu Roy, U.,Rahimi, N.,Ilghari, D.,Wang, H.,Chen, H.,Gai, W.,Blais, S.,Neubert, T.A.,Mansukhani, A.,Traaseth, N.J.,Li, X.,Mohammadi, M. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma. Mol.Cell, 61:98-110, 2016 Cited by PubMed: 26687682 DOI: 10.1016/j.molcel.2015.11.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.606 Å)

Structure validation