2PVF

Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide

Summary for 2PVF

Related2PSQ 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B
DescriptorFibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, transferase
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802 P21802
Total number of polymer chains2
Total molecular weight40871.48
Authors
Chen, H.,Mohammadi, M. (deposition date: 2007-05-09, release date: 2007-09-25, Last modification date: 2011-07-13)
Primary citation
Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M.
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27:717-730, 2007
PubMed: 17803937 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2007.06.028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26571.1%1.6%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2pvf
no rotation
Molmil generated image of 2pvf
rotated about x axis by 90°
Molmil generated image of 2pvf
rotated about y axis by 90°
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