2PVF

Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	HOH2
A	ACP300
A	ASN631
A	ASP644
B	HOH1

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	ACP300
A	HOH111
A	HOH112
A	HOH113
A	HOH114

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site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACP A 300

Chain	Residue
A	HOH57
A	HOH76
A	HOH112
A	MG301
A	MG302
A	LEU487
A	GLY488
A	GLY490
A	ALA491
A	PHE492
A	GLY493
A	VAL495
A	ALA515
A	LYS517
A	VAL564
A	GLU565
A	ALA567
A	ASN571
A	ARG630
A	ASN631
A	LEU633
A	ASP644
B	HOH1

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeavgidkdkpkeavt...VAVK

Chain	Residue	Details
A	LEU487-LYS517

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS622-VAL634

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:19060208

Chain	Residue	Details
B	TYR606

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208

Chain	Residue	Details
A	LEU487
A	LYS517
A	GLU565
A	ASN571

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646

Chain	Residue	Details
A	TYR466
A	TYR588

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646

Chain	Residue	Details
A	PTR586
A	PTR656
A	PTR657

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:19060208

Chain	Residue	Details
A	TYR769

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP626
A	ARG630

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP626
A	ALA628

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR661
A	ASP626
A	ALA628

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP626
A	ALA628
A	ASN631

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