2PVF
Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 2 | polymer | 334 | 38537.8 | 1 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (human) | FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen |
| 2 | B (B) | Fibroblast growth factor receptor 2 | polymer | 15 | 1779.9 | 1 | UniProt (P21802) | FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen | |
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 458 - 778 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Met 445 | - | expression tag |
| Gly 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Ser 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| Ser 455 | - | expression tag |
| Gln 456 | - | expression tag |
| Asp 457 | - | expression tag |
| Ala 491 | Cys 491 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40317.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 553.8 | |
| All* | Total formula weight | 40871.5 |
