2Q0B

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome

Summary for 2Q0B

Entry DOI	10.2210/pdb2q0b/pdb
Related	2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR
Descriptor	Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	kinase domain fold consisting of n- and c-lobes, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	2
Total formula weight	75499.75
Authors	Chen, H.,Mohammadi, M. (deposition date: 2007-05-21, release date: 2007-09-25, Last modification date: 2023-08-30)
Primary citation	Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27:717-730, 2007 Cited by PubMed: 17803937 DOI: 10.1016/j.molcel.2007.06.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation