Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome

Summary for 2Q0B

Related2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR
DescriptorFibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802
Total number of polymer chains2
Total molecular weight75499.75
Chen, H.,Mohammadi, M. (deposition date: 2007-05-21, release date: 2007-09-25, Last modification date: 2016-12-21)
Primary citation
Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M.
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27:717-730, 2007
PubMed: 17803937 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2007.06.028
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249141.3%3.4%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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