5EG3
Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 2 | polymer | 334 | 38155.7 | 1 | UniProt (P21802) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
2 | B | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | polymer | 114 | 13310.1 | 1 | UniProt (P10686) Pfam (PF00017) In PDB | Rattus norvegicus (Rat) | Phosphoinositide phospholipase C-gamma-1,Phospholipase C-gamma-1,PLC-gamma-1 |
3 | A | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 458 - 778 (UniProt: P21802)
B: 661 - 773 (UniProt: P10686)
PDB | External Database | Details |
---|---|---|
Met 445 | - | initiating methionine |
Gly 446 | - | expression tag |
Ser 447 | - | expression tag |
Ser 448 | - | expression tag |
His 449 | - | expression tag |
His 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
Ser 455 | - | expression tag |
Gln 456 | - | expression tag |
Asp 457 | - | expression tag |
Phe 466 | Tyr 466 | engineered mutation |
Ala 491 | Cys 491 | engineered mutation |
Ala 565 | Glu 565 | engineered mutation |
Leu 586 | Tyr 586 | engineered mutation |
Pro 588 | Tyr 588 | engineered mutation |
Phe 656 | Tyr 656 | engineered mutation |
Phe 657 | Tyr 657 | engineered mutation |
Glu 659 | Lys 659 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 660 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 51465.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 553.8 | |
All* | Total formula weight | 52019.6 |