7YSW

Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex

Summary for 7YSW

Entry DOI	10.2210/pdb7ysw/pdb
EMDB information	34084
Descriptor	Fibroblast growth factor receptor 4, Klotho, Fibroblast growth factor 23, ... (6 entities in total)
Functional Keywords	fgf hormones, fgf receptor, klotho co-receptor, heparan sulfate glycosaminoglycans, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	179194.76
Authors	Mohammadi, M.,Chen, L. (deposition date: 2022-08-13, release date: 2023-06-14, Last modification date: 2023-07-05)
Primary citation	Chen, L.,Fu, L.,Sun, J.,Huang, Z.,Fang, M.,Zinkle, A.,Liu, X.,Lu, J.,Pan, Z.,Wang, Y.,Liang, G.,Li, X.,Chen, G.,Mohammadi, M. Structural basis for FGF hormone signalling. Nature, 618:862-870, 2023 Cited by PubMed: 37286607 DOI: 10.1038/s41586-023-06155-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation