7YSW
Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003085 | biological_process | negative regulation of systemic arterial blood pressure |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004566 | molecular_function | beta-glucuronidase activity |
| A | 0005104 | molecular_function | fibroblast growth factor receptor binding |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005499 | molecular_function | vitamin D binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006112 | biological_process | energy reserve metabolic process |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0008422 | molecular_function | beta-glucosidase activity |
| A | 0008543 | biological_process | fibroblast growth factor receptor signaling pathway |
| A | 0014823 | biological_process | response to activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0017134 | molecular_function | fibroblast growth factor binding |
| A | 0030501 | biological_process | positive regulation of bone mineralization |
| A | 0033280 | biological_process | response to vitamin D |
| A | 0042421 | biological_process | norepinephrine biosynthetic process |
| A | 0055074 | biological_process | calcium ion homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071774 | biological_process | response to fibroblast growth factor |
| A | 0090080 | biological_process | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| A | 1990776 | biological_process | response to angiotensin |
| B | 0008083 | molecular_function | growth factor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00653 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWAvGsAAYQtEgG |
| Chain | Residue | Details |
| A | PHE65-GLY79 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 176 |
| Details | Domain: {"description":"Ig-like C2-type 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Domain: {"description":"Ig-like C2-type 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 438 |
| Details | Region: {"description":"Glycosyl hydrolase-1 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by proprotein convertases"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"31932717","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc) threonine","evidences":[{"source":"PubMed","id":"31932717","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc) threonine","evidences":[{"source":"PubMed","id":"16638743","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31932717","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
