2FDB

Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c

Summary for 2FDB

Entry DOI	10.2210/pdb2fdb/pdb
Descriptor	fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2 (3 entities in total)
Functional Keywords	beta-trefoil fold; immunoglobulin fold, hormone-growth factor-transferase complex, hormone/growth factor/transferase
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P55075 Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: Q9UQH9
Total number of polymer chains	4
Total formula weight	87329.55
Authors	Mohammadi, M.,Olsen, S.K. (deposition date: 2005-12-13, release date: 2006-02-07, Last modification date: 2023-08-30)
Primary citation	Olsen, S.K.,Li, J.Y.H.,Bromleigh, C.,Eliseenkova, A.V.,Ibrahimi, O.A.,Lao, Z.,Zhang, F.,Linhardt, R.J.,Joyner, A.L.,Mohammadi, M. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain Genes Dev., 20:185-198, 2006 Cited by PubMed: 16384934 DOI: 10.1101/gad.1365406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation