7YSH

Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex

Summary for 7YSH

Entry DOI	10.2210/pdb7ysh/pdb
EMDB information	34075
Descriptor	Klotho, Fibroblast growth factor 23, Isoform 20 of Fibroblast growth factor receptor 1, ... (6 entities in total)
Functional Keywords	fgf hormones, fgf receptor, klotho co-receptor, heparan sulfate glycosaminoglycans, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	195055.95
Authors	Mohammadi, M.,Chen, L. (deposition date: 2022-08-12, release date: 2023-04-19, Last modification date: 2023-07-05)
Primary citation	Chen, L.,Fu, L.,Sun, J.,Huang, Z.,Fang, M.,Zinkle, A.,Liu, X.,Lu, J.,Pan, Z.,Wang, Y.,Liang, G.,Li, X.,Chen, G.,Mohammadi, M. Structural basis for FGF hormone signalling. Nature, 618:862-870, 2023 Cited by PubMed: 37286607 DOI: 10.1038/s41586-023-06155-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation