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7YSH

Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
A0004566molecular_functionbeta-glucuronidase activity
A0005104molecular_functionfibroblast growth factor receptor binding
A0005179molecular_functionhormone activity
A0005499molecular_functionvitamin D binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0006112biological_processenergy reserve metabolic process
A0008340biological_processdetermination of adult lifespan
A0008422molecular_functionbeta-glucosidase activity
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0014823biological_processresponse to activity
A0016324cellular_componentapical plasma membrane
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0017134molecular_functionfibroblast growth factor binding
A0030501biological_processpositive regulation of bone mineralization
A0033280biological_processresponse to vitamin D
A0042421biological_processnorepinephrine biosynthetic process
A0055074biological_processcalcium ion homeostasis
A0070062cellular_componentextracellular exosome
A0071774biological_processresponse to fibroblast growth factor
A0090080biological_processpositive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
A1990776biological_processresponse to angiotensin
B0000165biological_processMAPK cascade
B0005104molecular_functionfibroblast growth factor receptor binding
B0005105molecular_functiontype 1 fibroblast growth factor receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005796cellular_componentGolgi lumen
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009887biological_processanimal organ morphogenesis
B0010628biological_processpositive regulation of gene expression
B0010966biological_processregulation of phosphate transport
B0010980biological_processpositive regulation of vitamin D 24-hydroxylase activity
B0030154biological_processcell differentiation
B0030334biological_processregulation of cell migration
B0030500biological_processregulation of bone mineralization
B0030502biological_processnegative regulation of bone mineralization
B0030643biological_processintracellular phosphate ion homeostasis
B0032026biological_processresponse to magnesium ion
B0042359biological_processvitamin D metabolic process
B0042369biological_processvitamin D catabolic process
B0043410biological_processpositive regulation of MAPK cascade
B0044320biological_processcellular response to leptin stimulus
B0045668biological_processnegative regulation of osteoblast differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046888biological_processnegative regulation of hormone secretion
B0055062biological_processphosphate ion homeostasis
B0055074biological_processcalcium ion homeostasis
B0070371biological_processERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071305biological_processcellular response to vitamin D
B0071354biological_processcellular response to interleukin-6
B0071374biological_processcellular response to parathyroid hormone stimulus
B0090080biological_processpositive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
B1904383biological_processresponse to sodium phosphate
Functional Information from PROSITE/UniProt
site_idPS00653
Number of Residues15
DetailsGLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWAvGsAAYQtEgG
ChainResidueDetails
APHE65-GLY79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN227
EASN330
DASN240
DASN264
DASN317
DASN330
EASN227
EASN240
EASN264
EASN317

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
DASN296
EASN296
AASN283
AASN344
AASN607
AASN612
AASN694

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:31932717
ChainResidueDetails
BTHR171

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:31932717
ChainResidueDetails
BTHR178

224931

PDB entries from 2024-09-11

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