7YSH
Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Klotho | polymer | 948 | 109164.8 | 1 | UniProt (Q9UEF7) Pfam (PF00232) In PDB | Homo sapiens (human) | |
2 | B | Fibroblast growth factor 23 | polymer | 273 | 30367.0 | 1 | UniProt (Q9GZV9) Pfam (PF00167) In PDB | Homo sapiens (human) | FGF-23,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor |
3 | D, E | Isoform 20 of Fibroblast growth factor receptor 1 | polymer | 234 | 26373.0 | 2 | UniProt (P11362-20) Pfam (PF07679) UniProt (by SIFTS) (P11362) In PDB | Homo sapiens (human) | FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr,"c" splice isoform of FGFR1,FGFR1c |
4 | F | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 2649.2 | 1 | In PDB GlyTouCan (G10608JX) | |||
5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
6 | D | COPPER (II) ION | non-polymer | 63.5 | 1 | Chemie (CU) |
Sequence modifications
B: 25 - 251 (UniProt: Q9GZV9)
D, E: 142 - 366 (UniProt: P11362-20)
PDB | External Database | Details |
---|---|---|
Met -21 | - | initiating methionine |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
Gly -12 | - | expression tag |
Leu -11 | - | expression tag |
Val -10 | - | expression tag |
Pro -9 | - | expression tag |
Arg -8 | - | expression tag |
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Gly -5 | - | expression tag |
Met -4 | - | expression tag |
Lys -3 | - | expression tag |
Glu -2 | - | expression tag |
Thr -1 | - | expression tag |
Ala 0 | - | expression tag |
Ala 1 | - | expression tag |
Ala 2 | - | expression tag |
Lys 3 | - | expression tag |
Phe 4 | - | expression tag |
Glu 5 | - | expression tag |
Arg 6 | - | expression tag |
Gln 7 | - | expression tag |
His 8 | - | expression tag |
Met 9 | - | expression tag |
Asp 10 | - | expression tag |
Ser 11 | - | expression tag |
Pro 12 | - | expression tag |
Asp 13 | - | expression tag |
Leu 14 | - | expression tag |
Gly 15 | - | expression tag |
Thr 16 | - | expression tag |
Asp 17 | - | expression tag |
Asp 18 | - | expression tag |
Asp 19 | - | expression tag |
Asp 20 | - | expression tag |
Lys 21 | - | expression tag |
Ala 22 | - | expression tag |
Met 23 | - | expression tag |
Gly 24 | - | expression tag |
Gln 176 | Arg 176 | variant |
Gln 179 | Arg 179 | variant |
PDB | External Database | Details |
---|---|---|
Gly 367 | - | expression tag |
Thr 368 | - | expression tag |
Lys 369 | - | expression tag |
His 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
His 373 | - | expression tag |
His 374 | - | expression tag |
His 375 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 192277.8 | |
Branched | Number of molecules | 1 |
Total formula weight | 2649.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 129.0 | |
All* | Total formula weight | 195055.9 |