6SMW
| A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed | Descriptor: | 1,2-ETHANEDIOL, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Ruszkowski, M, Sekula, B, Dauter, Z. | Deposit date: | 2019-08-23 | Release date: | 2020-01-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9, 2019
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6JHJ
| Structure of Marine bacterial laminarinase mutant-E135A | Descriptor: | CALCIUM ION, LamCAT | Authors: | Yang, J, Xu, Y, Miyakawa, T, Tanokura, M, Long, L. | Deposit date: | 2019-02-18 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Molecular Basis for Substrate Recognition and Catalysis by a Marine Bacterial Laminarinase. Appl.Environ.Microbiol., 86, 2020
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1J3E
| Crystal Structure of the E.coli SeqA protein complexed with N6-methyladenine- guanine mismatch DNA | Descriptor: | 5'-D(*AP*AP*GP*GP*(6MA)P*TP*CP*CP*AP*A)-3', 5'-D(*TP*TP*GP*GP*AP*GP*CP*CP*TP*T)-3', SeqA protein | Authors: | Fujikawa, N, Kurumizaka, H, Nureki, O, Tanaka, Y, Yamazoe, M, Hiraga, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-01-24 | Release date: | 2004-05-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and biochemical analyses of hemimethylated DNA binding by the SeqA protein Nucleic Acids Res., 32, 2004
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4ORZ
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4J34
| Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved. | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | Authors: | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | Deposit date: | 2013-02-05 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural basis of kynurenine 3-monooxygenase inhibition. Nature, 496, 2013
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3FDW
| Crystal structure of a C2 domain from human synaptotagmin-like protein 4 | Descriptor: | Synaptotagmin-like protein 4 | Authors: | Bonanno, J.B, Rutter, M, Bain, K.T, Miller, S, Romero, R, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-11-26 | Release date: | 2008-12-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a C2 domain from human synaptotagmin-like protein 4 To be Published
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6SO5
| Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer | Descriptor: | ATPase ASNA1, Calcium signal-modulating cyclophilin ligand, Tail-anchored protein insertion receptor WRB, ... | Authors: | McDowell, M.A, Heimes, M, Wild, K, Flemming, D, Sinning, I. | Deposit date: | 2019-08-29 | Release date: | 2020-09-09 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex. Mol.Cell, 80, 2020
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4IX6
| Crystal structure of a Stt7 homolog from Micromonas algae soaked with ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MsStt7d protein | Authors: | Guo, J, Wei, X, Li, M, Pan, X, Chang, W, Liu, Z. | Deposit date: | 2013-01-24 | Release date: | 2013-10-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae Protein Cell, 4, 2013
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3PZD
| Structure of the myosin X MyTH4-FERM/DCC complex | Descriptor: | GLYCEROL, Myosin-X, Netrin receptor DCC | Authors: | Wei, Z, Yan, J, Pan, L, Zhang, M. | Deposit date: | 2010-12-14 | Release date: | 2011-02-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain Proc.Natl.Acad.Sci.USA, 108, 2011
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4OUU
| anti-MT1-MMP monoclonal antibody | Descriptor: | anti_MT1-MMP Heavy chain, anti_MT1-MMP light chain | Authors: | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Koziol, A, Cuniasse, P, Dive, V, Arroyo, A.G, Irit, S, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2014-02-19 | Release date: | 2014-12-17 | Last modified: | 2015-01-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure, 23, 2015
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3EW7
| Crystal structure of the Lmo0794 protein from Listeria monocytogenes. Northeast Structural Genomics Consortium target LmR162. | Descriptor: | Lmo0794 protein | Authors: | Vorobiev, S.M, Abashidze, M, Seetharaman, J, Wang, D, Foote, E.L, Ciccosanti, C, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-10-14 | Release date: | 2008-11-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Crystal structure of the Lmo0794 protein from Listeria monocytogenes. To be Published
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6SOX
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-carbamoylbenzoic acid | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-aminocarbonylbenzoic acid, DIMETHYL SULFOXIDE, ... | Authors: | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | Deposit date: | 2019-08-30 | Release date: | 2020-09-09 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SIQ
| Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface | Descriptor: | 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... | Authors: | Leysen, S, Wolter, M, Guillory, X, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. | Deposit date: | 2019-08-10 | Release date: | 2020-06-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.60121 Å) | Cite: | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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3FER
| Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. | Descriptor: | ACETIC ACID, Filamin-B | Authors: | Kuzin, A.P, Abashidze, M, Seetharaman, R, Shastry, R, Sahdev, S, Ciccosanti, C, Xiao, R, Everett, J.K, Huang, Y, Acton, T, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-11-30 | Release date: | 2009-01-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. To be Published
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1IXK
| Crystal Structure Analysis of Methyltransferase Homolog Protein from Pyrococcus Horikoshii | Descriptor: | Methyltransferase | Authors: | Ishikawa, I, Sakai, N, Yao, M, Watanabe, N, Tamura, T, Tanaka, I. | Deposit date: | 2002-06-25 | Release date: | 2003-09-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human p120 homologue protein PH1374 from Pyrococcus horikoshii PROTEINS: STRUCT.,FUNCT.,GENET., 54, 2004
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6SJF
| Cryo-EM structure of the RecBCD Chi unrecognised complex | Descriptor: | Forked DNA substrate, RecBCD enzyme subunit RecB, RecBCD enzyme subunit RecC, ... | Authors: | Cheng, K, Wilkinson, M, Wigley, D.B. | Deposit date: | 2019-08-13 | Release date: | 2020-01-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair. Nat.Struct.Mol.Biol., 27, 2020
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6F10
| GLIC mutant D88N | Descriptor: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | Authors: | Hu, H.D, Delarue, M. | Deposit date: | 2017-11-21 | Release date: | 2018-01-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel. PLoS Biol., 15, 2017
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4OU7
| Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1 | Authors: | Liu, Z, Chen, P, Niu, L, Teng, M, Li, X. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res., 42, 2014
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1IY0
| Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus | Descriptor: | ATP-dependent metalloprotease FtsH, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Niwa, H, Tsuchiya, D, Makyio, H, Yoshida, M, Morikawa, K. | Deposit date: | 2002-07-10 | Release date: | 2002-11-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8 Structure, 10, 2002
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4IZK
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4OBZ
| Structure of Cathepsin D with inhibitor 2-(3,4-dimethoxyphenyl)-N-[N-(4-methylbenzyl)carbamimidoyl]acetamide | Descriptor: | 2-(3,4-dimethoxyphenyl)-N-[N-(4-methylbenzyl)carbamimidoyl]acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Graedler, U, Czodrowski, P, Tsaklakidis, C, Klein, M, Maskos, K, Leuthner, B. | Deposit date: | 2014-01-08 | Release date: | 2014-08-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-based optimization of non-peptidic Cathepsin D inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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3Q27
| Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP) | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2010-12-19 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.302 Å) | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation Protein Sci., 20, 2011
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4IUL
| MIF4G domain of DAP5 | Descriptor: | Eukaryotic translation initiation factor 4 gamma 2, SULFATE ION | Authors: | Frank, F, Virgili, G, Feoktistova, K, Sawicki, M, Sonenberg, N, Fraser, C, Nagar, B. | Deposit date: | 2013-01-21 | Release date: | 2013-03-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A. Structure, 21, 2013
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4OVK
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6SBC
| Structure of type II terpene cyclase MstE from Scytonema in complex with farnesyl dihydroxybenzoate | Descriptor: | CHLORIDE ION, MstE, SODIUM ION, ... | Authors: | Moosmann, P, Ecker, F, Leopold-Messer, S, Cahn, J.K.B, Groll, M, Piel, J. | Deposit date: | 2019-07-19 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds. Nat.Chem., 12, 2020
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